固体分散体技术对纳米雄黄稳定性及体外溶出的影响研究(5)
[17] 刘嵘，濮德敏，赵立波，等. 纳米雄黄混悬液诱导Siha细胞凋亡及对HPV16E6/E7表达的影响[J]. 中国中药杂志，2008， 33(1)： 54.
Effect of stability and dissolution of realgar nano-particles
using solid dispersion technology
GUO Teng， SHI Feng， YANG Gang， FENG Nian-ping(College of Pharmacy， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)
[Abstract] Objective： To improve the stability and dissolution of realgar nano-particles by solid dispersion. Method： Using polyethylene glycol 6000 and poloxamer-188 as carriers， the solid dispersions were prepare by melting method. XRD， microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As203 were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions. Result： The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly， the reunion of realgar nano-particles and content of As203 were reduced for the formation of solid dispersions. Conclusion： The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability， dissolution and solubility.
[Key words] realgar nano-particles； solid dispersion； stability； dissolution
doi：10.4268/cjcmm20131709
[责任编辑 曹阳阳], 百拇医药(郭腾 施峰 杨刚 冯年平)
Effect of stability and dissolution of realgar nano-particles
using solid dispersion technology
GUO Teng， SHI Feng， YANG Gang， FENG Nian-ping(College of Pharmacy， Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China)
[Abstract] Objective： To improve the stability and dissolution of realgar nano-particles by solid dispersion. Method： Using polyethylene glycol 6000 and poloxamer-188 as carriers， the solid dispersions were prepare by melting method. XRD， microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As203 were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions. Result： The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly， the reunion of realgar nano-particles and content of As203 were reduced for the formation of solid dispersions. Conclusion： The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability， dissolution and solubility.
[Key words] realgar nano-particles； solid dispersion； stability； dissolution
doi：10.4268/cjcmm20131709
[责任编辑 曹阳阳], 百拇医药(郭腾 施峰 杨刚 冯年平)