中药群体药代动力学专家共识(征求意见稿)
2.Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China；
3.Hunan University of Chinese Medicine， Changsha 410208， China；
4. Third Hospital， Peking University， Beijing 100191， China)
[Abstract] In population pharmacokinetic (PPK) research of Chinese medicines with narrow therapeutic windows of toxicity， or when the target population is not homogeneous， or when there are frequent adverse reactions to parenterally administered Chinese medicine， select those that have a definite therapeutic effect， and in which the compositions of the toxic substances compositions are known， for study， and use complete PPK sampling design to take samples at specific time points. Use gas chromatography， HPLC， and LC-MS methods for the detection of target components. Finally， use total quantity statistical moment analysis， to account for each component of the PPK parameters. Thus， PPK model can reflect the overall trend of Chinese medicine， to provide the basis for reasonable clinical dosage adjustments.
[Key words] Chinese medicine； population pharmacokinetics； expert consensus
doi：10.4268/cjcmm20131805, 百拇医药(谢雁鸣 王建农 贺福元 姜俊杰 熊昕)
3.Hunan University of Chinese Medicine， Changsha 410208， China；
4. Third Hospital， Peking University， Beijing 100191， China)
[Abstract] In population pharmacokinetic (PPK) research of Chinese medicines with narrow therapeutic windows of toxicity， or when the target population is not homogeneous， or when there are frequent adverse reactions to parenterally administered Chinese medicine， select those that have a definite therapeutic effect， and in which the compositions of the toxic substances compositions are known， for study， and use complete PPK sampling design to take samples at specific time points. Use gas chromatography， HPLC， and LC-MS methods for the detection of target components. Finally， use total quantity statistical moment analysis， to account for each component of the PPK parameters. Thus， PPK model can reflect the overall trend of Chinese medicine， to provide the basis for reasonable clinical dosage adjustments.
[Key words] Chinese medicine； population pharmacokinetics； expert consensus
doi：10.4268/cjcmm20131805, 百拇医药(谢雁鸣 王建农 贺福元 姜俊杰 熊昕)