口服中药多组分现代缓释制剂体系的构建(5)
Chinese Medicine， Nanjing 210028， China；
2. Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Traditional Chinese medicines have a long history， with a large quantity of efficient traditional Chinese medicines and prescriptions. However， the vast majority of pharmaceutical dose forms remain common preparations， with very few efficient， long-lasting and low-dose preparations. The sustain-release preparation allows sustained drug release in a longer period of time， maintains blood drug concentration， reduces the toxic effect and medication frequency， and improves medication compliance. Unlike monomer drugs， the material base of traditional Chinese medicine and compounds is multi-component， instead of single or several active monomers. Therefore， under the guidance of the Chinese medicine theories， modern multi-component sustained-release preparations were developed for oral traditional Chinese medicines， with the aim of finally improving the clinical efficacy of traditional Chinese medicines.
[Key words] traditional Chinese medicine； component； sustained-release preparation； in vitro and in vivo evaluation
doi：10.4268/cjcmm20131936, 百拇医药(夏海建 张振海 刘丹 郁丹红 贾晓斌)
2. Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Traditional Chinese medicines have a long history， with a large quantity of efficient traditional Chinese medicines and prescriptions. However， the vast majority of pharmaceutical dose forms remain common preparations， with very few efficient， long-lasting and low-dose preparations. The sustain-release preparation allows sustained drug release in a longer period of time， maintains blood drug concentration， reduces the toxic effect and medication frequency， and improves medication compliance. Unlike monomer drugs， the material base of traditional Chinese medicine and compounds is multi-component， instead of single or several active monomers. Therefore， under the guidance of the Chinese medicine theories， modern multi-component sustained-release preparations were developed for oral traditional Chinese medicines， with the aim of finally improving the clinical efficacy of traditional Chinese medicines.
[Key words] traditional Chinese medicine； component； sustained-release preparation； in vitro and in vivo evaluation
doi：10.4268/cjcmm20131936, 百拇医药(夏海建 张振海 刘丹 郁丹红 贾晓斌)