延胡索物质基础研究(9)
3. State Key Laboratory of Natural and Biomimetic Drugs， Department of Natural Medicines， School of Pharmaceutical Sciences，Peking University， Beijing 100191， China)
[Abstract] Corydalis Rhizoma， the dried tuber of Corydalis yanhusuo (Papaveraceae) distributed traditionally mainly in southeastern and now cultivated in northwestern and other district in China， is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain， abdominal pain， pain due to injury， and promote blood circulation. Its main chemical constituents were alkaloids， which were divided into the two types of protoberberines and aporphines. Among them， some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system， which plays an important role in regulating nociception. In this article， the chemical composition and structure-types， new methods of qualitative and quantitative analysis as well as characteristics of biotransformation， absorption， distribution， metabolism， excretion， pharmacokinetic， and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.
[Key words] dried tuber of Corydalis yanhusuo； alkaloid； bioactive material base
doi：10.4268/cjcmm20140105
[责任编辑 孔晶晶], 百拇医药(杨鑫宝 杨秀伟 刘建勋)
[Abstract] Corydalis Rhizoma， the dried tuber of Corydalis yanhusuo (Papaveraceae) distributed traditionally mainly in southeastern and now cultivated in northwestern and other district in China， is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain， abdominal pain， pain due to injury， and promote blood circulation. Its main chemical constituents were alkaloids， which were divided into the two types of protoberberines and aporphines. Among them， some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system， which plays an important role in regulating nociception. In this article， the chemical composition and structure-types， new methods of qualitative and quantitative analysis as well as characteristics of biotransformation， absorption， distribution， metabolism， excretion， pharmacokinetic， and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.
[Key words] dried tuber of Corydalis yanhusuo； alkaloid； bioactive material base
doi：10.4268/cjcmm20140105
[责任编辑 孔晶晶], 百拇医药(杨鑫宝 杨秀伟 刘建勋)