丹酚酸组分磷脂复合物制备研究(5)
[Abstract]To prepare salvianolic acid phospholipid compound. With the compound of salvianolic acids and soybean phospholipid as the index， mono-factor experiment and orthogonal design experiment were conducted to screen its technical parameters. According to the results， the optimal preparation conditions of salvianolic acid phospholipid compound were that THF were taken as the reaction solvent， the concentration time was 3 h， the reactant concentration was 5 g·L-1， the mass ratio of salvianolic acids and phospholipid was 1∶1.5， and the reaction temperature was 40 ℃. The oil/water partition coefficient of the prepared salvianolic acid phospholipid compound significant increased in water and buffers with different pH values. The results of phase analysis such as DSC， XRD and FTIR indicated that salvianolic acids existed in phospholipid in an amorphous state.
[Key words]salvianolic acids； phospholipid compound； oil/water partition coefficient； characterization
doi：10.4268/cjcmm20140211
[责任编辑马超一], http://www.100md.com(陈小云 张振海 刘丹 郁丹红 孙娥 贾晓斌)
[Key words]salvianolic acids； phospholipid compound； oil/water partition coefficient； characterization
doi：10.4268/cjcmm20140211
[责任编辑马超一], http://www.100md.com(陈小云 张振海 刘丹 郁丹红 孙娥 贾晓斌)