提取动力学模型的简化及黄芩总黄酮模型适应性研究(4)
total flavonoids model of Scutellariae Radix
CHEN Yang， ZHANG Jin， NI Jian*， DONG Xiao-xu， XU Meng-jie， DOU Hao-ran， SHEN Ming-rui， YANG Bo-di， FU Jing
(School of Chinese Material Medica， Beijing University of Chinese Medicine， Beijing 100102， China)
[Abstract]Because of irregular shapes of Chinese herbal pieces， we simplified the previously deduced general extraction kinetic model for TCMs， and integrated particle diameters of Chinese herbs that had been hard to be determined in the final parameter "a". The reduction of the direct determination of particle diameters of Chinese herbs was conducive to increase the accuracy of the model， expand the application scope of the model， and get closer to the actual production conditions. Finally， a simplified model was established， with its corresponding experimental methods and data processing methods determined. With total flavonoids in Scutellariae Radix as the determination index， we conducted a study on the adaptability of total flavonoids extracted from Scutellariae Radix with the water decoction method in the model. The results showed a good linear correlation among the natural logarithm value of the mass concentration of total flavonoids in Scutellariae Radix， the time and the changes in the natural logarithm of solvent multiple. Through calculating and fitting， efforts were made to establish the kinetic model of extracting total flavonoids from Scutellariae Radix with the water decoction method， and verify the model， with a good degree of fitting and deviation within the range of the industrial production requirements. This indicated that the model established by the method has a good adaptability.
[Key words]model simplification； extraction dynamics； Scutellariae Radix； total flavonoids； adaptability
doi：10.4268/cjcmm20140213
[责任编辑马超一], http://www.100md.com(陈杨 张晋 倪健 董晓旭 徐梦洁 豆浩然 申明睿 杨博迪 付京)
CHEN Yang， ZHANG Jin， NI Jian*， DONG Xiao-xu， XU Meng-jie， DOU Hao-ran， SHEN Ming-rui， YANG Bo-di， FU Jing
(School of Chinese Material Medica， Beijing University of Chinese Medicine， Beijing 100102， China)
[Abstract]Because of irregular shapes of Chinese herbal pieces， we simplified the previously deduced general extraction kinetic model for TCMs， and integrated particle diameters of Chinese herbs that had been hard to be determined in the final parameter "a". The reduction of the direct determination of particle diameters of Chinese herbs was conducive to increase the accuracy of the model， expand the application scope of the model， and get closer to the actual production conditions. Finally， a simplified model was established， with its corresponding experimental methods and data processing methods determined. With total flavonoids in Scutellariae Radix as the determination index， we conducted a study on the adaptability of total flavonoids extracted from Scutellariae Radix with the water decoction method in the model. The results showed a good linear correlation among the natural logarithm value of the mass concentration of total flavonoids in Scutellariae Radix， the time and the changes in the natural logarithm of solvent multiple. Through calculating and fitting， efforts were made to establish the kinetic model of extracting total flavonoids from Scutellariae Radix with the water decoction method， and verify the model， with a good degree of fitting and deviation within the range of the industrial production requirements. This indicated that the model established by the method has a good adaptability.
[Key words]model simplification； extraction dynamics； Scutellariae Radix； total flavonoids； adaptability
doi：10.4268/cjcmm20140213
[责任编辑马超一], http://www.100md.com(陈杨 张晋 倪健 董晓旭 徐梦洁 豆浩然 申明睿 杨博迪 付京)