玳玳黄酮提取物特征活性成分不同生理状态的药动学特性比较(5)
(Department of Pharmacy， Fujian University of Traditional Chinese Medicine， Fuzhou 350122， China)
[Abstract]In order to explore the clinical hypolipidemic features of Daidai flavone extract， the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats were studied and compared. The study established the quantitative determination method of naringin and neohesperidin in plasma by UPLC-MS. Study compared the pharmacokinetics differences of naringin and noehesperidin in normal and hyperlipemia rats on the basis of establishment of hyperlipemia model. Results indicated that the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats showed significant differences. The Cmax of naringin and neohesperidin in hyperlipemia rats plasma after oral administration of Daidai flavone extract increased obviously， while t1/2， MRT and AUC0-24 h decreased， compared to normal rats. But tmax showed no differences to that of normal rats. The results further proved Daidai flavone extract would have better hypolipidemic effect in the hyperlipemia pathological status. And the characteristic active ingredients naringin and noehesperidin were the material base of Daidai flavone extract to express the hypolipidemic effect.
[Key words]Daidai flavone extract； UPLC-MS； hyperlipidaemia； pharmacokinetics
doi：10.4268/cjcmm20140229
[责任编辑陈玲], http://www.100md.com(曾令军 陈丹 郑利 连赟芳 蔡韦炜 黄群 林伊莉)
[Abstract]In order to explore the clinical hypolipidemic features of Daidai flavone extract， the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats were studied and compared. The study established the quantitative determination method of naringin and neohesperidin in plasma by UPLC-MS. Study compared the pharmacokinetics differences of naringin and noehesperidin in normal and hyperlipemia rats on the basis of establishment of hyperlipemia model. Results indicated that the pharmacokinetics features of characteristic active ingredients of Daidai flavone extract in normal and hyperlipemia rats showed significant differences. The Cmax of naringin and neohesperidin in hyperlipemia rats plasma after oral administration of Daidai flavone extract increased obviously， while t1/2， MRT and AUC0-24 h decreased， compared to normal rats. But tmax showed no differences to that of normal rats. The results further proved Daidai flavone extract would have better hypolipidemic effect in the hyperlipemia pathological status. And the characteristic active ingredients naringin and noehesperidin were the material base of Daidai flavone extract to express the hypolipidemic effect.
[Key words]Daidai flavone extract； UPLC-MS； hyperlipidaemia； pharmacokinetics
doi：10.4268/cjcmm20140229
[责任编辑陈玲], http://www.100md.com(曾令军 陈丹 郑利 连赟芳 蔡韦炜 黄群 林伊莉)