整合药理学：中药现代研究新模式(6)
[34] Li S. Network systems underlying traditional Chinese medicine syndrome and herb formula[J].Curr Bioinform，2009， 4 (3)： 188.
[35] 张兆旺，孙秀梅.半仿生提取法的特点与应用[J]. 提取技术与工艺， 2000， 2(1)： 35.
[36] 孙海燕，廖晓慧，彭光华. Caco-2细胞模型及其在食品营养物质吸收研究中的新进展[J].时珍国医国药，2007， 18 (10)： 2573.
[37] Wilson T H， Wiseman G. The use of sacs of evened small intestine for the study of the transference of substances from the mucosal to the serosal surface[J].Physiol， 1954，123(1)：116.
[38] 陈万平，孙翔，程鹏远. 体外药物肝代谢研究进展[J].第四军医大学学报， 2008，29 (9)： 861.
[39] 左风，严梅桢，周钟鸣. 肠道菌群对中药有效成分代谢作用的研究进展[J].中国中药杂志，2002， 27(8)： 568.
Integrative pharmacology： new paradigm of modernization of Chinese medicine
XU Hai-yu， YANG Hong-jun(Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China)
[Abstract] Chinese medicinal formulae(CMF) were often used in the clinics of traditional Chinese medicine (TCM) which were critical for modernization of Chinese medicine to shed light on the interaction between CMF and biological organisms. In current studies， correlation between system and part， macroscopic actions and microcosmic mechanism， ADME process and pharmacologic actions were often neglected. Thus， we put forward integrative pharmacology， which could integrate the correlation between CMF and biological organisms from multi-levels and multi-dimensional views. Integrative pharmacology would reveal the molecular mechanism of CMF for ailments treatment and screen out effective material systematically， which would be the new paradigm of TCM research.
[Key words] integrative pharmacology； Chinese medicinal formulae； the molecular mechanism of Chinese medicinal formulae； modernization of Chinese medicine
doi：10.4268/cjcmm20140302
[责任编辑 陈玲], http://www.100md.com(许海玉 杨洪军)
[35] 张兆旺，孙秀梅.半仿生提取法的特点与应用[J]. 提取技术与工艺， 2000， 2(1)： 35.
[36] 孙海燕，廖晓慧，彭光华. Caco-2细胞模型及其在食品营养物质吸收研究中的新进展[J].时珍国医国药，2007， 18 (10)： 2573.
[37] Wilson T H， Wiseman G. The use of sacs of evened small intestine for the study of the transference of substances from the mucosal to the serosal surface[J].Physiol， 1954，123(1)：116.
[38] 陈万平，孙翔，程鹏远. 体外药物肝代谢研究进展[J].第四军医大学学报， 2008，29 (9)： 861.
[39] 左风，严梅桢，周钟鸣. 肠道菌群对中药有效成分代谢作用的研究进展[J].中国中药杂志，2002， 27(8)： 568.
Integrative pharmacology： new paradigm of modernization of Chinese medicine
XU Hai-yu， YANG Hong-jun(Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China)
[Abstract] Chinese medicinal formulae(CMF) were often used in the clinics of traditional Chinese medicine (TCM) which were critical for modernization of Chinese medicine to shed light on the interaction between CMF and biological organisms. In current studies， correlation between system and part， macroscopic actions and microcosmic mechanism， ADME process and pharmacologic actions were often neglected. Thus， we put forward integrative pharmacology， which could integrate the correlation between CMF and biological organisms from multi-levels and multi-dimensional views. Integrative pharmacology would reveal the molecular mechanism of CMF for ailments treatment and screen out effective material systematically， which would be the new paradigm of TCM research.
[Key words] integrative pharmacology； Chinese medicinal formulae； the molecular mechanism of Chinese medicinal formulae； modernization of Chinese medicine
doi：10.4268/cjcmm20140302
[责任编辑 陈玲], http://www.100md.com(许海玉 杨洪军)