辣椒碱立方液晶纳米粒的制备及体外评价(3)
[11] Mura S，Pirot F，Manconi M，et al. Liposomes and niosomes as potential carriers for dermal delivery of minoxidil [J]. J Drug Target，2007，15(2)：101.
[12] Bender J，Ericson M，Merclin N，et al. Lipid cubic phases for improved topical drug delivery in photodynamic therapy [J]. J Control Release，2005，106(3)：350.
[13] 龙晓英，罗佳波，严志红，等. 局部用辣椒碱传递体的制备及体内外评价[J]. 药学学报，2006，41(5)：461.
Preparation and in vitro study on diffusion of capsaicin cubosome
PENG Xin-sheng1，ZHOU Yan-fang1，HAN Ke2，QIN Ling-zhen3，WU Chuan-bin3*
(1. School of Pharmaceutical Sciences，Guangdong Medical College，Dongguan 523808，China；
2.The Second Affiliated Hospital of Guangzhou Medical University，Guangzhou 510260，China；
3. School of Pharmaceutical Sciences，Sun Yat-Sen University，Guangzhou 510006，China)
[Abstract] This study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However，the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group (P<0.01). Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system.
[Key words] cubosome；capsaicin；diffusion；skin-targeted
doi：10.4268/cjcmm20140418, 百拇医药(彭新生 周艳芳 韩珂 覃玲珍 吴传斌)
[12] Bender J，Ericson M，Merclin N，et al. Lipid cubic phases for improved topical drug delivery in photodynamic therapy [J]. J Control Release，2005，106(3)：350.
[13] 龙晓英，罗佳波，严志红，等. 局部用辣椒碱传递体的制备及体内外评价[J]. 药学学报，2006，41(5)：461.
Preparation and in vitro study on diffusion of capsaicin cubosome
PENG Xin-sheng1，ZHOU Yan-fang1，HAN Ke2，QIN Ling-zhen3，WU Chuan-bin3*
(1. School of Pharmaceutical Sciences，Guangdong Medical College，Dongguan 523808，China；
2.The Second Affiliated Hospital of Guangzhou Medical University，Guangzhou 510260，China；
3. School of Pharmaceutical Sciences，Sun Yat-Sen University，Guangzhou 510006，China)
[Abstract] This study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However，the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group (P<0.01). Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system.
[Key words] cubosome；capsaicin；diffusion；skin-targeted
doi：10.4268/cjcmm20140418, 百拇医药(彭新生 周艳芳 韩珂 覃玲珍 吴传斌)