微粉化对黄芩苷粉体学性质的影响(3)
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Effects of micronization on micromeritics properties of baicalin
YAN Hong-mei1，2，DING Dong-mei1，SUN E1，WANG Jing1，JIA Xiao-bin1，2*，ZHANG Zhen-hai1*
(1.Key Laboratory of New Drug Delivery System of Chinese Materia Medica，Jiangsu Provincial Academy of
Chinese Medicine，Nanjing 210028，China；
2. Nanjing University of Chinese Medicine，Nanjing 210046，China)
[Abstract] Baicalin extremely fine powder was made by using ball-mill and the effect of micronization on the micromeritics properties of baicalin was studied and analyzed. The microstructures of baicalin ordinary and extremely fine powder were compared by scanning electron microscope，differential scanning calorimeter and X-ray diffraction and the powder characteristic of them was investigated. The hygroscopicity was studied. The effect of micronization on the dissolution of baicalin was investigated. The results showed that the chemical constituents of baicalin were not changed after micronization with better compressibility. It was confirmed that micronization technology had a certain application value in promoting the insoluble component of baicalin absorption with higher dissolution.
[Key words] baicalin；micronization；pharmaceutical properties；microstructures；dissolution
doi：10.4268/cjcmm20140420, 百拇医药(严红梅 丁冬梅 孙娥 汪晶 贾晓斌 张振海)
Effects of micronization on micromeritics properties of baicalin
YAN Hong-mei1，2，DING Dong-mei1，SUN E1，WANG Jing1，JIA Xiao-bin1，2*，ZHANG Zhen-hai1*
(1.Key Laboratory of New Drug Delivery System of Chinese Materia Medica，Jiangsu Provincial Academy of
Chinese Medicine，Nanjing 210028，China；
2. Nanjing University of Chinese Medicine，Nanjing 210046，China)
[Abstract] Baicalin extremely fine powder was made by using ball-mill and the effect of micronization on the micromeritics properties of baicalin was studied and analyzed. The microstructures of baicalin ordinary and extremely fine powder were compared by scanning electron microscope，differential scanning calorimeter and X-ray diffraction and the powder characteristic of them was investigated. The hygroscopicity was studied. The effect of micronization on the dissolution of baicalin was investigated. The results showed that the chemical constituents of baicalin were not changed after micronization with better compressibility. It was confirmed that micronization technology had a certain application value in promoting the insoluble component of baicalin absorption with higher dissolution.
[Key words] baicalin；micronization；pharmaceutical properties；microstructures；dissolution
doi：10.4268/cjcmm20140420, 百拇医药(严红梅 丁冬梅 孙娥 汪晶 贾晓斌 张振海)