基于机械粉碎法的穿心莲内酯复合粒子制备及其溶出度研究(4)
Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China；
2. Key Laboratory of Modern Preparation of Traditional Chinese Medicine under Ministry of Education，Jiangxi University of Traditional Chinese Medicine，Nanchang 330004，China；
3. Jiangxi College of Traditional Chinese Medicine，Fuzhou 344000，China；
4. Sichuan Houde Medical Technology Co.，Ltd.，Chengdu 611731，China)
[Abstract] Objective： To prepare andrographolide composite particles，and evaluate their particle structure and dissolution. Method： The mechanical crushing method was adopted to prepare andrographolide and polyethylene glycol (PEG) 6000 composite particles. The structures were characterized by the scanning electron microscope (SEM) and the differential scanning calorimeter (DSC). The contact angles were determined by the contact angle analyzer. The in vitro dissolution curve was detected. Result： Andrographolide and PEG 6000 gave rise to coated composite particle structures，with the decrease in the crystallinity of andrographolide. The in vitro dissolution rate of composite particles was significantly obvious than that of its raw materials，ultrafine powder and their physical mixtures. Conclusion： Andrographolide composite particles based on the mechanical crushing method could notably enhance the in vitro dissolution of andrographolide.
[Key words] andrographolide；mechanical crushing method；composite particle；dissolution
doi：10.4268/cjcmm20140421, http://www.100md.com(王小平 韩丽 任桂林 张定堃 伍振峰 杨明 郭治平)
2. Key Laboratory of Modern Preparation of Traditional Chinese Medicine under Ministry of Education，Jiangxi University of Traditional Chinese Medicine，Nanchang 330004，China；
3. Jiangxi College of Traditional Chinese Medicine，Fuzhou 344000，China；
4. Sichuan Houde Medical Technology Co.，Ltd.，Chengdu 611731，China)
[Abstract] Objective： To prepare andrographolide composite particles，and evaluate their particle structure and dissolution. Method： The mechanical crushing method was adopted to prepare andrographolide and polyethylene glycol (PEG) 6000 composite particles. The structures were characterized by the scanning electron microscope (SEM) and the differential scanning calorimeter (DSC). The contact angles were determined by the contact angle analyzer. The in vitro dissolution curve was detected. Result： Andrographolide and PEG 6000 gave rise to coated composite particle structures，with the decrease in the crystallinity of andrographolide. The in vitro dissolution rate of composite particles was significantly obvious than that of its raw materials，ultrafine powder and their physical mixtures. Conclusion： Andrographolide composite particles based on the mechanical crushing method could notably enhance the in vitro dissolution of andrographolide.
[Key words] andrographolide；mechanical crushing method；composite particle；dissolution
doi：10.4268/cjcmm20140421, http://www.100md.com(王小平 韩丽 任桂林 张定堃 伍振峰 杨明 郭治平)