小叶臭黄皮中单萜和倍半萜类成分研究(5)
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Monoterpenes and sesquiterpenes from Clausena excavata
PENG Wen-wen1，2，3， SONG Wei-wu2， HUANG Mao-bo2， TAN Ning-hua2*
(1.Jiangxi Key Laboratory of Natural Products and Functional Food， Jiangxi Agricultural University， Nanchang 330045， China；
2. State Key Laboratory of Phytochemistry and Plant Resources in West China， Kunming Institute of
Botany， Chinese Academy of Sciences， Kunming 650201， China；
3.College of Agriculture， Jiangxi Agricultural University， Nanchang 330045， China)
[Abstract] To investigate monoterpenes and sesquiterpenes of the stems and leaves of Clausena excavata， an AcOEt fraction of the methanol extract was subjected on column chromatographies including silica gel and RP-18， as well as preparative HPLC. The structures of compounds isolated were identified on the basis of spectroscopic data as excamonoterpene(1)，(6R， 9S)-9， 10-dihydroxy-4-megastigmen-3-one(2)，(3R， 6R， 7E)-3-hydroxy-4， 7-megastigmadien-9-one(3)，(3S)-3-hydroxy-7， 8-dihydro-β-ionone(4)，(3S，5R，6S)-3-hydroxy-5，6-epoxy-β-ionone(5)， (6R，9R)-9-hydroxy-4-megastigmen-3-one(6)，(3S， 5R)-dihydroxy-6， 7-megstigmadien-9-one(7)，(-)-loliolide(8)， caryolane-1，9α-diol(9) and 2， 6-dihydroxyhumula-3(12)， 7(13)， 9(E)-triene(10)， were isolated from the stems and leaves of C. excavata. Compound 1 is a new monoterpene， named as excamonoterpene. Compounds 2-10 were isolated from this plant for the first time.
[Key words] Rutaceae； Clausena excavata； monoterpenes； sesquiterpenes
doi：10.4268/cjcmm20140915, 百拇医药(彭文文 宋卫武 黄茂波 谭宁华)
Monoterpenes and sesquiterpenes from Clausena excavata
PENG Wen-wen1，2，3， SONG Wei-wu2， HUANG Mao-bo2， TAN Ning-hua2*
(1.Jiangxi Key Laboratory of Natural Products and Functional Food， Jiangxi Agricultural University， Nanchang 330045， China；
2. State Key Laboratory of Phytochemistry and Plant Resources in West China， Kunming Institute of
Botany， Chinese Academy of Sciences， Kunming 650201， China；
3.College of Agriculture， Jiangxi Agricultural University， Nanchang 330045， China)
[Abstract] To investigate monoterpenes and sesquiterpenes of the stems and leaves of Clausena excavata， an AcOEt fraction of the methanol extract was subjected on column chromatographies including silica gel and RP-18， as well as preparative HPLC. The structures of compounds isolated were identified on the basis of spectroscopic data as excamonoterpene(1)，(6R， 9S)-9， 10-dihydroxy-4-megastigmen-3-one(2)，(3R， 6R， 7E)-3-hydroxy-4， 7-megastigmadien-9-one(3)，(3S)-3-hydroxy-7， 8-dihydro-β-ionone(4)，(3S，5R，6S)-3-hydroxy-5，6-epoxy-β-ionone(5)， (6R，9R)-9-hydroxy-4-megastigmen-3-one(6)，(3S， 5R)-dihydroxy-6， 7-megstigmadien-9-one(7)，(-)-loliolide(8)， caryolane-1，9α-diol(9) and 2， 6-dihydroxyhumula-3(12)， 7(13)， 9(E)-triene(10)， were isolated from the stems and leaves of C. excavata. Compound 1 is a new monoterpene， named as excamonoterpene. Compounds 2-10 were isolated from this plant for the first time.
[Key words] Rutaceae； Clausena excavata； monoterpenes； sesquiterpenes
doi：10.4268/cjcmm20140915, 百拇医药(彭文文 宋卫武 黄茂波 谭宁华)