TRPV1离子通道与中药辛味药性的关系研究(5)
[32] 于新宇，柳青. 瞬时受体电位香草酸亚型1在心血管系统中的调节作用[J].心血管病学进展，2012，33(2)：282.
[33] 张培，李江，王耘，等.贝叶斯网络在中药有效组分五味预测中的应用[J].世界科学技术——中医药现代化，2008(5)：114.
Study on relations between transient receptor potential vanilloid 1 and
pungent property of traditional Chinese medicines
WANG Xing， ZHANG Yan-ling， WANG Yun， REN Zhen-zhen， BAO Hong-juan， QIAO Yan-jiang
(1.Information Engineering Research Center for Traditional Chinese Medicine，Beijing University of Chinese Medicine， Beijing 100102， China；
2. Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Development of
Fujian Province， Xiamen Medical College， Xiamen 361008， China)
[Abstract] The five-flavor theory of traditional Chinese medicines(TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper， by using the pharmacophore-based virtual screening technique， the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components′ role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore， the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components， and consistent with the inherited and additive characteristics.
[Key words] TRPV1 ion channel； pungent property； pharmacophore； virtual screening
doi：10.4268/cjcmm20141314
[责任编辑 张宁宁], 百拇医药(王星 张燕玲 王耘 任真真 鲍红娟 乔延江)
[33] 张培，李江，王耘，等.贝叶斯网络在中药有效组分五味预测中的应用[J].世界科学技术——中医药现代化，2008(5)：114.
Study on relations between transient receptor potential vanilloid 1 and
pungent property of traditional Chinese medicines
WANG Xing， ZHANG Yan-ling， WANG Yun， REN Zhen-zhen， BAO Hong-juan， QIAO Yan-jiang
(1.Information Engineering Research Center for Traditional Chinese Medicine，Beijing University of Chinese Medicine， Beijing 100102， China；
2. Key Laboratory of Traditional Chinese Medicine Finish Processing and Health Product Development of
Fujian Province， Xiamen Medical College， Xiamen 361008， China)
[Abstract] The five-flavor theory of traditional Chinese medicines(TCM) and the flavor efficacy generation mechanism has long been focuses and difficulties in studies on traditional Chinese medicinal properties. In this paper， by using the pharmacophore-based virtual screening technique， the authors discussed the relations between the pungent property and transient receptor potential vanilloid 1 (TRPV1) by studying the TCM components′ role in regulating TRPV1 ion channel. The results showed that the matching relationship between TRPV1 agonist pharmacophore model and TCM chemical components could identify the active ingredients from pungent herbs. Therefore， the authors proposed that TRPV1 is one of the potential targets for efficient pungent herbs. The pungent property of TCMs is decided by its chemical components， and consistent with the inherited and additive characteristics.
[Key words] TRPV1 ion channel； pungent property； pharmacophore； virtual screening
doi：10.4268/cjcmm20141314
[责任编辑 张宁宁], 百拇医药(王星 张燕玲 王耘 任真真 鲍红娟 乔延江)