钩藤神经保护机制的研究进展(7)
[52] Lamm S， Sheng Y， Pero R W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa，C-Med-100[J]. Phytomedicine， 2001， 8(4)： 267.
[53] Hsieh C L， Ho T Y， Su S Y， et al. Uncaria rhynchophylla and rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-κB activity in kainic acid-treated rats[J]. Am J Chin Med， 2009， 37(2)： 351.
Advance in studies on neuroprotective mechanism of Uncariae
Ramulus Cum Uncis
WEI Fang-fang， ZENG Chang-qing*， ZHAO Yu-hong， LIU Lin
(School of Chinese Medicine， Guangdong Pharmaceutical University， Guangzhou 510006， China)
[Abstract] The Uncariae Ramulus Cum Uncis is a commonly used traditional Chinese medicine. In recent years， many studies have revealed its prominent neuroprotection function. The active ingredients in Uncariae Ramulus Cum Uncis could protect the nervous system in a multi-path and multi-target manner. Uncariae Ramulus Cum Uncis shows the neuroprotective effect by resisting oxidation， scavenging free radicals， modulating neurotransmitters and their related receptors， regulating the inflammatory factors and their related pathways， attenuating neuron apoptosis， reducing intracellular Ca2+ overloads and mitigating neurodegeneration. In this paper， the authors summarized the advance in studies on neuroprotective mechanisms of Uncariae Ramulus Cum Uncis.
[Key words] Uncariae Ramulus Cum Uncis； active ingredient； antioxidant； neuroprotection
doi：10.4268/cjcmm20141403
[责任编辑 张宁宁], http://www.100md.com(韦芳芳 曾常青 赵宇红 刘林)
[53] Hsieh C L， Ho T Y， Su S Y， et al. Uncaria rhynchophylla and rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-κB activity in kainic acid-treated rats[J]. Am J Chin Med， 2009， 37(2)： 351.
Advance in studies on neuroprotective mechanism of Uncariae
Ramulus Cum Uncis
WEI Fang-fang， ZENG Chang-qing*， ZHAO Yu-hong， LIU Lin
(School of Chinese Medicine， Guangdong Pharmaceutical University， Guangzhou 510006， China)
[Abstract] The Uncariae Ramulus Cum Uncis is a commonly used traditional Chinese medicine. In recent years， many studies have revealed its prominent neuroprotection function. The active ingredients in Uncariae Ramulus Cum Uncis could protect the nervous system in a multi-path and multi-target manner. Uncariae Ramulus Cum Uncis shows the neuroprotective effect by resisting oxidation， scavenging free radicals， modulating neurotransmitters and their related receptors， regulating the inflammatory factors and their related pathways， attenuating neuron apoptosis， reducing intracellular Ca2+ overloads and mitigating neurodegeneration. In this paper， the authors summarized the advance in studies on neuroprotective mechanisms of Uncariae Ramulus Cum Uncis.
[Key words] Uncariae Ramulus Cum Uncis； active ingredient； antioxidant； neuroprotection
doi：10.4268/cjcmm20141403
[责任编辑 张宁宁], http://www.100md.com(韦芳芳 曾常青 赵宇红 刘林)