现代医学对恶性肿瘤转移相关机制的研究进展(7)
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[49] 刘求真，姚开泰. 肿瘤干细胞与肿瘤转移[J]. 肿瘤学杂志， 2008(1)： 10.
[50] 庄静，孙长岗，梁艳，等. 肿瘤干细胞学说及相关性中药作用机理的研究[J]. 世界中西医结合杂志， 2013(3)： 275.
[51] 郭华，张宁. 上皮间充质转化与肿瘤干细胞的研究进展[J]. 中国肿瘤临床， 2013(15)： 941.
Research progress on mechanisms of modern medicine in cancer metastasis
CHEN Hui， QU Jing-lian， GONG Jie-ning
(Basic Institute in Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Cancer metastasis is the most dangerous stage of tumorigenesis and evolution， the primary cause of death in cancer patients. Clinically， more than 60% of cancer patients have found metastasis at the time of examination. Modern medicine has made significant progress on the mechanisms of cancer metastasis in recent years， from the simple ″anatomy and machinery″ theory forward to the ″seed and soil″ theory， then to the ″microenvironmental″ theory and the ″cancer stem cell″ theory. The emerging ″cancer stem cell″ theory successfully explains phenomenon such as tumor genetic heterogeneity， anoikis resistance， tumor dormancy， providing more new targets and ideas for the diagnosis and treatment of cancer metastasis.
[Key words] modern medicine； cancer； metastasis mechanism； epithelial-mesenchymal transition； cancer stem cell
doi：10.4268/cjcmm20141507
[责任编辑 陈玲], 百拇医药(陈惠 渠景连 龚婕宁)
[48] 张英，林洪生. 肿瘤干细胞在肿瘤复发与转移中的作用[J]. 中国肿瘤， 2008(2)： 125.
[49] 刘求真，姚开泰. 肿瘤干细胞与肿瘤转移[J]. 肿瘤学杂志， 2008(1)： 10.
[50] 庄静，孙长岗，梁艳，等. 肿瘤干细胞学说及相关性中药作用机理的研究[J]. 世界中西医结合杂志， 2013(3)： 275.
[51] 郭华，张宁. 上皮间充质转化与肿瘤干细胞的研究进展[J]. 中国肿瘤临床， 2013(15)： 941.
Research progress on mechanisms of modern medicine in cancer metastasis
CHEN Hui， QU Jing-lian， GONG Jie-ning
(Basic Institute in Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Cancer metastasis is the most dangerous stage of tumorigenesis and evolution， the primary cause of death in cancer patients. Clinically， more than 60% of cancer patients have found metastasis at the time of examination. Modern medicine has made significant progress on the mechanisms of cancer metastasis in recent years， from the simple ″anatomy and machinery″ theory forward to the ″seed and soil″ theory， then to the ″microenvironmental″ theory and the ″cancer stem cell″ theory. The emerging ″cancer stem cell″ theory successfully explains phenomenon such as tumor genetic heterogeneity， anoikis resistance， tumor dormancy， providing more new targets and ideas for the diagnosis and treatment of cancer metastasis.
[Key words] modern medicine； cancer； metastasis mechanism； epithelial-mesenchymal transition； cancer stem cell
doi：10.4268/cjcmm20141507
[责任编辑 陈玲], 百拇医药(陈惠 渠景连 龚婕宁)