中药促治疗性血管新生防治缺血性心脑血管疾病的研究进展(1)
[摘要]缺血性心脑血管疾病遗留的器质性损伤和功能障碍一直是困扰临床医生的难题。内皮祖细胞的发现使人们意识到出生后血管新生作为一个重要的生物学过程，对修复缺血区域组织损伤，恢复损伤组织功能具有重要作用。基于此治疗性血管新生的概念的提出为治疗缺血性心脑血管疾病提供了一种新的方式。中医药在治疗缺血导致的心脑血管损伤疾病方面具有广泛的临床经验，近年来研究发现大量中药及复方制剂具有促治疗性血管新生的作用，而其作用机制不完全相同，主要表现在增加血管新生调节因子，促进EPCs的增殖、分化和迁移等方面。该综述检索近期文献，总结具有促治疗性血管新生作用的传统中药复方或单体成分，并进行归纳分析其不同的作用途径，以期为今后中医药促治疗性血管新生研究提供参考。
[关键词]治疗性血管新生;缺血性心脑血管疾病
[收稿日期]2014-06-06
[基金项目]国家“重大新药创制”科技重大专项(2012ZX09103201-049，2012ZX09301002-004)
, http://www.100md.com
[通信作者]*刘建勋，研究员，Tel：(010)62874049，E-mail：liujx0324@sina.com
[作者简介]郭浩，助理研究员，主要从事中医药防治心血管疾病的基础药理学研究，E-mail：g0502g@163.com
Advance in prevention and treatment of ischemia cardio-cerebrovascular disease
through increased therapeutic angiogenesis induced by traditional Chinese medicine
GUO Hao1，2， LI Lei1，2， HOU Jin-cai1，2， LIU Jian-xun1，2*
, http://www.100md.com
(1. Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China;
2. Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing 100091， China)
[Abstract]Remaining organic and functional damage of ischemia cardio-cerebrovascular disease is always a main trouble puzzling the clinicians. After the discovery of endothelial progenitor cells (EPCs)， researchers realize that postnatal angiogenesis is an important biological process， which play a key role to repair the ischemia tissue and improve the function. So a new concept which names therapeutic angiogenesis supply a new treament way for the ischemia cardio-cerebrovascular disease. Traditional Chinese medicine(TCM) has accumulated rich experience on treating the ischemia disease， studies found that many Chinese medicine prescriptions and effective ingredients can increase the therapeutic angiogenesis， howerer the mechanisms were not the same， they mainly manifest in regular the secretion of angiogenic factors， increase the proliferation and differentiation etc. In this paper， we review recent studies， summary the Chinese medicine prescriptions and effective ingredients which can increase the therapeutic angiogenesis， and analyze the differernt pathway. We view to provide reference for the later researchers.
, http://www.100md.com
[Key words]therapeutic angiogenesis; ischemia cardio-cerebrovascular disease
doi：10.4268/cjcmm20150105
血管新生(angiogenesis)是生物体通过自身反馈调节，在原有的毛细血管与/或微静脉基础上通过血管ECs的增殖和迁移，以芽生或非芽生(或称套迭)的形式生成新的毛细血管，进而形成复杂血管系统的关键步骤[1]。在生理或病理条件下血管新生对血管系统均发挥重要作用，它既是机体正常发育、生殖和组织修复的基础[2]，也与某些疾病的病理过程如慢性炎症、肿瘤的生长和伤口愈合等息息相关。血管新生功能的异常是多种疾病发生根本原因，在冠心病，中风，伤口愈合延迟等病变过程中，血管新生不足将会导致循环障碍和组织坏死[3]，无法满足机体生长需要。反之，在肿瘤、糖尿病眼病和风湿性关节炎等疾病中，过度的血管新生将会导致病理组织过度增长，进而损坏正常组织。, http://www.100md.com(郭浩 李磊 侯金才 刘建勋)
[关键词]治疗性血管新生;缺血性心脑血管疾病
[收稿日期]2014-06-06
[基金项目]国家“重大新药创制”科技重大专项(2012ZX09103201-049，2012ZX09301002-004)
, http://www.100md.com
[通信作者]*刘建勋，研究员，Tel：(010)62874049，E-mail：liujx0324@sina.com
[作者简介]郭浩，助理研究员，主要从事中医药防治心血管疾病的基础药理学研究，E-mail：g0502g@163.com
Advance in prevention and treatment of ischemia cardio-cerebrovascular disease
through increased therapeutic angiogenesis induced by traditional Chinese medicine
GUO Hao1，2， LI Lei1，2， HOU Jin-cai1，2， LIU Jian-xun1，2*
, http://www.100md.com
(1. Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091， China;
2. Beijing Key Laboratory of Chinese Materia Pharmacology， Beijing 100091， China)
[Abstract]Remaining organic and functional damage of ischemia cardio-cerebrovascular disease is always a main trouble puzzling the clinicians. After the discovery of endothelial progenitor cells (EPCs)， researchers realize that postnatal angiogenesis is an important biological process， which play a key role to repair the ischemia tissue and improve the function. So a new concept which names therapeutic angiogenesis supply a new treament way for the ischemia cardio-cerebrovascular disease. Traditional Chinese medicine(TCM) has accumulated rich experience on treating the ischemia disease， studies found that many Chinese medicine prescriptions and effective ingredients can increase the therapeutic angiogenesis， howerer the mechanisms were not the same， they mainly manifest in regular the secretion of angiogenic factors， increase the proliferation and differentiation etc. In this paper， we review recent studies， summary the Chinese medicine prescriptions and effective ingredients which can increase the therapeutic angiogenesis， and analyze the differernt pathway. We view to provide reference for the later researchers.
, http://www.100md.com
[Key words]therapeutic angiogenesis; ischemia cardio-cerebrovascular disease
doi：10.4268/cjcmm20150105
血管新生(angiogenesis)是生物体通过自身反馈调节，在原有的毛细血管与/或微静脉基础上通过血管ECs的增殖和迁移，以芽生或非芽生(或称套迭)的形式生成新的毛细血管，进而形成复杂血管系统的关键步骤[1]。在生理或病理条件下血管新生对血管系统均发挥重要作用，它既是机体正常发育、生殖和组织修复的基础[2]，也与某些疾病的病理过程如慢性炎症、肿瘤的生长和伤口愈合等息息相关。血管新生功能的异常是多种疾病发生根本原因，在冠心病，中风，伤口愈合延迟等病变过程中，血管新生不足将会导致循环障碍和组织坏死[3]，无法满足机体生长需要。反之，在肿瘤、糖尿病眼病和风湿性关节炎等疾病中，过度的血管新生将会导致病理组织过度增长，进而损坏正常组织。, http://www.100md.com(郭浩 李磊 侯金才 刘建勋)