塔中栽培荒漠肉苁蓉中的木脂素类成分(1)
[摘要]对新疆塔中栽培荒漠肉苁蓉Cistanche deserticola干燥肉质茎的化学成分进行研究。采用多种色谱技术(正相硅胶、凝胶 Sephadex LH-20，MCI，ODS以及半制备高效液相色谱等) 进行分离纯化，运用 NMR、MS等波谱方法以及结合文献数据对分离得到的化合物进行结构鉴定。结果从塔中栽培荒漠肉苁蓉干燥肉质茎85%乙醇提取物中分离得到11个木脂素类化合物，其结构分别鉴定为：(+)-丁香脂素-4′-O-β-D-吡喃葡萄糖苷(1)，(+)-isoeucommin A(2)，(+)-麦奥迪脂素-4′-O-β-D-吡喃葡萄糖苷(3)，(+)-松脂素单甲基醚-β-D-葡萄糖苷(4)，落叶松脂醇-4′-O-β-D-葡萄糖苷(5)，落叶松脂醇-4-O-β-D-葡萄糖苷(6)，conicaoside(7)，dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(8)，dehydrodiconiferyl alcohol γ′-O-β-D-glucoside(9)，橙皮素A(10)，阿拉善苷A(11)。其中化合物1，3～7，10，11为首次从该属植物中分离得到，化合物2，8，9为首次从该植物中分离得到。
, 百拇医药
[关键词]荒漠肉苁蓉; 木脂素; 化学成分; 结构鉴定
[收稿日期]2014-11-16
[基金项目]国家“重大新药创制”科技重大专项(2012ZX09201201-001， 2012ZX09301002-002-002， 2012ZX09304-005);国家中医药管理局中医药科学技术研究专项(201307002)
[通信作者]*屠鹏飞，Tel/Fax：(010)82802750，E-mail：pengfeitu@vip.163.com;*姜勇，Tel/Fax：(010)82802719，E-mail：yongjiang@bjmu.edu.cn
[作者简介]南泽东，博士研究生，E-mail：nanzedong1@aliyun.comLignans from stems of Cistanche deserticola
, 百拇医药
cultured in Tarim desert
NAN Ze-dong1，2， ZHAO Ming-bo1， JIANG Yong1*， TU Peng-fei1*
(1.State Key Laboratory of Natural and Biomimetic Drugs， School of Pharmaceutical Sciences，Peking University Health Science Center， Beijing 100191， China;
2. College of Traditional Chinese Medicine， Shanxi University of Traditioanl Chinese Medicine， Taiyuan 030619， China)
[Abstract]In order to clarify the chemical constituents of Cistanche deserticola cultured in Tarim desert， a systematically phytochemical investigation was carried out. The chemical constituents were isolated by column chromatography， such as silica gel， Sephadex LH-20， MCI gel， ODS and semi-preparative HPLC， and their structures were determined on the basis of MS， NMR spectroscopic analysis and/or comparison with literature data. Eleven lignans were isolated from the 85% ethanol extract of the stems of C. deserticola cultured in Tarim desert. Their structures were identified as (+)-syringaresinol-4′-O-β-D-glucopyranoside (1)， (+)-isoeucommin A (2)， eucommin A (3)， (+)-pinoresinol monomethylether β-D-glucoside (4)， lariciresinol 4′-O-β-D- glucopyranoside (5)， lariciresinol 4-O-β-D-glucopyranoside (6)， conicaoside (7)， dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8)， dehydrodiconiferyl alcohol γ′-O-β-D-glucoside (9)， citrusin A (10)，and alaschanioside A (11). Compounds 1， 3-7， 10 and 11 were isolated from this genus for the first time， and compounds 2， 8 and 9 were obtained from this species for the first time.
[Key words]Cistanche deserticola; Lignans; Chemical constituents; Structure elucidation, http://www.100md.com(南泽东 赵明波 姜勇 屠鹏飞)
, 百拇医药
[关键词]荒漠肉苁蓉; 木脂素; 化学成分; 结构鉴定
[收稿日期]2014-11-16
[基金项目]国家“重大新药创制”科技重大专项(2012ZX09201201-001， 2012ZX09301002-002-002， 2012ZX09304-005);国家中医药管理局中医药科学技术研究专项(201307002)
[通信作者]*屠鹏飞，Tel/Fax：(010)82802750，E-mail：pengfeitu@vip.163.com;*姜勇，Tel/Fax：(010)82802719，E-mail：yongjiang@bjmu.edu.cn
[作者简介]南泽东，博士研究生，E-mail：nanzedong1@aliyun.comLignans from stems of Cistanche deserticola
, 百拇医药
cultured in Tarim desert
NAN Ze-dong1，2， ZHAO Ming-bo1， JIANG Yong1*， TU Peng-fei1*
(1.State Key Laboratory of Natural and Biomimetic Drugs， School of Pharmaceutical Sciences，Peking University Health Science Center， Beijing 100191， China;
2. College of Traditional Chinese Medicine， Shanxi University of Traditioanl Chinese Medicine， Taiyuan 030619， China)
[Abstract]In order to clarify the chemical constituents of Cistanche deserticola cultured in Tarim desert， a systematically phytochemical investigation was carried out. The chemical constituents were isolated by column chromatography， such as silica gel， Sephadex LH-20， MCI gel， ODS and semi-preparative HPLC， and their structures were determined on the basis of MS， NMR spectroscopic analysis and/or comparison with literature data. Eleven lignans were isolated from the 85% ethanol extract of the stems of C. deserticola cultured in Tarim desert. Their structures were identified as (+)-syringaresinol-4′-O-β-D-glucopyranoside (1)， (+)-isoeucommin A (2)， eucommin A (3)， (+)-pinoresinol monomethylether β-D-glucoside (4)， lariciresinol 4′-O-β-D- glucopyranoside (5)， lariciresinol 4-O-β-D-glucopyranoside (6)， conicaoside (7)， dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8)， dehydrodiconiferyl alcohol γ′-O-β-D-glucoside (9)， citrusin A (10)，and alaschanioside A (11). Compounds 1， 3-7， 10 and 11 were isolated from this genus for the first time， and compounds 2， 8 and 9 were obtained from this species for the first time.
[Key words]Cistanche deserticola; Lignans; Chemical constituents; Structure elucidation, http://www.100md.com(南泽东 赵明波 姜勇 屠鹏飞)