组分结构中药与网络药理学：病理机制网络的系统整体调控(1)
[摘要]疾病的发生发展是多种因素参与的生物网络变化的结果。药物干预的本质是将这种病理变化调控至正常范围。中药的优势在于通过多靶点、多层次、多途径地整体和系统性调控这种生物网络病理改变。组分结构中药为这种调控提供了可控、精确的“物”的基础，又通过网络药理学调控阐明“理”的本质。组分结构中药与网络药理学的密切结合为创新中药提供了一种新的研究策略，改变了传统用药的“一个药物、一个基因、一种疾病”的模式，体现疾病发生发展的整体特点，也充分体现中医药防病治病的内涵本质。该研究系统探讨了组分结构中药与网络药理学的结合本质、特点以及研究策略，从改善或恢复生物网络平衡的整体观角度来认识组分结构中药与机体的相互作用，成为揭示组分结构中药调控疾病生物网络机制的有效措施，也为进一步科学的研究创新组分结构中药提供新的思路和方法。
[关键词]组分结构中药;网络药理学;病理网络调控
Structural components of Chinese medicine and pharmacology network：
, 百拇医药
systematical overall regulation on pathological network
CHEN Juan1，2， GU Jun-fei3， WANG Chun-fei2， YUAN Jia-rui2， ZHAO Bing-jie2， ZHANG Li2，CHENG Xu-dong3， FENG Liang2*， JIA Xiao-bin2
(1. Co-Innovation Center for Structural Components of Chinese Materia Medica， School of Pharmacy，Nanjing University of Chinese Medicine， Nanjing 210023， China;
2. Key Laboratory of New Drug Delivery System of Chinese Materia Medica， Jiangsu Provincial Academy of
, 百拇医药
Chinese Medicine， Nanjing 210028， China;
3. ALG (Suzhou) Medical science & technology Co.， Ltd.， Suzhou 215125， China)
[Abstract]Development of the disease is the result of several factors involved in biological network changes. The nature of drug intervention is to regulate these pathological changes to the normal range. Advantages of traditional Chinese medicine (TCM) are to integrally and systematically regulate this biological networks and systematic pathology through multi-targets， multi-levels， multi-channels. Structural components TCM provides the controlled and precise basis ″substance″ for this regulation and also to clarify the ″truth″ of the nature of the regulation by the network pharmacology. Network pharmacology provides new strategy for the research on mechanism of structural components TCM. This study not only reflects the overall characteristics of the development of the disease， but also fully embodies the essence of TCM for preventing and treating diseases through changing traditional model on ″one drug， one gene， one disease″. This paper explores systematically the integration essence， features and research strategies of structural components TCM and the network pharmacology， understand the interaction of structural components TCM and body from the perspective of the overall concept of improving or restoring the balance of biological networks. It is effective measure to reveal the structure of a multi-component for regulating biological networks mechanisms， and also provide new ideas and methods for further scientific research and innovation of structural component TCM., 百拇医药(陈娟 顾俊菲 汪春飞 袁嘉瑞 赵冰洁 章丽 成旭东 封亮 贾晓斌)
[关键词]组分结构中药;网络药理学;病理网络调控
Structural components of Chinese medicine and pharmacology network：
, 百拇医药
systematical overall regulation on pathological network
CHEN Juan1，2， GU Jun-fei3， WANG Chun-fei2， YUAN Jia-rui2， ZHAO Bing-jie2， ZHANG Li2，CHENG Xu-dong3， FENG Liang2*， JIA Xiao-bin2
(1. Co-Innovation Center for Structural Components of Chinese Materia Medica， School of Pharmacy，Nanjing University of Chinese Medicine， Nanjing 210023， China;
2. Key Laboratory of New Drug Delivery System of Chinese Materia Medica， Jiangsu Provincial Academy of
, 百拇医药
Chinese Medicine， Nanjing 210028， China;
3. ALG (Suzhou) Medical science & technology Co.， Ltd.， Suzhou 215125， China)
[Abstract]Development of the disease is the result of several factors involved in biological network changes. The nature of drug intervention is to regulate these pathological changes to the normal range. Advantages of traditional Chinese medicine (TCM) are to integrally and systematically regulate this biological networks and systematic pathology through multi-targets， multi-levels， multi-channels. Structural components TCM provides the controlled and precise basis ″substance″ for this regulation and also to clarify the ″truth″ of the nature of the regulation by the network pharmacology. Network pharmacology provides new strategy for the research on mechanism of structural components TCM. This study not only reflects the overall characteristics of the development of the disease， but also fully embodies the essence of TCM for preventing and treating diseases through changing traditional model on ″one drug， one gene， one disease″. This paper explores systematically the integration essence， features and research strategies of structural components TCM and the network pharmacology， understand the interaction of structural components TCM and body from the perspective of the overall concept of improving or restoring the balance of biological networks. It is effective measure to reveal the structure of a multi-component for regulating biological networks mechanisms， and also provide new ideas and methods for further scientific research and innovation of structural component TCM., 百拇医药(陈娟 顾俊菲 汪春飞 袁嘉瑞 赵冰洁 章丽 成旭东 封亮 贾晓斌)