基于数据挖掘的注意缺陷多动障碍中医用药规律研究(1)
[摘要]选取公开发表文献中辨治ADHD的有效中医复方88首，建立用药数据库，采用频数分析、关联规则分析、聚类分析对药物功效、性味归经、配伍规律进行数据挖掘。结果显示，使用频率≥10%的药物有33味，前12位中药依次为石菖蒲、远志、熟地黄、龙骨、甘草、茯苓、牡蛎、龟甲、白芍、五味子、山茱萸、山药，为ADHD常用药物。使用频率前7位的药物类别依次为补虚药、安神药、平肝熄风药、清热药、收涩药、开窍药、利水渗湿药;药性以温、寒、平为主，以温为最;药味以甘、苦、辛为主，以甘为首;归经以肝、心、肾为主;关联规则分析得出常用的药对如远志→石菖蒲、牡蛎→龙骨、远志→熟地黄等。高频药物聚类分析得到8个聚类方。研究表明中医治疗ADHD用药以补虚(滋补肝肾，补益心脾)、安神为基本组方配伍，兼顾平肝(为主)、清热、理气、活血、化痰、熄风等，契合病机;多种数据挖掘技术结合能更全面和客观地反映ADHD临床用药规律。
[关键词]注意力缺陷多动障碍;用药规律;数据挖掘;频数分析;关联规则;聚类分析
, 百拇医药
StudyonmedicationregularityoftraditionalChinesemedicinesintreating
attentiondeficithyperactivitydisorderbasedondatamining
NIXin-qiang/1，HANXin-min1*，YINDong-qi/1，LIUCheng-quan/1
(1.FirstClinicalMedicineCollege，NanjingUniversityofTraditionalChineseMedicine，Nanjing210046，China;
2.DepartmentofTraditionalChineseMedicine，Huai′anMaternalandChildHealthCareHospital，Huai′an223002，China)
, 百拇医药
[Abstract]Inthisstudy，effortsweremadetocollect88traditionalChinesemedicine(TCM)prescriptionsfortreatingADHDfrompublicliteratures，establishamedicationdatabaseandconductdataminingontheefficacy，properties，tastes，meridianentriesandcompatibilityregularityofTCMsbyusingfrequencyanalysis，associationrulesanalysisandclusteranalysis.Theresultsshowed33herbswithahighfrequency(≥10%).Thetop12frequentlyappliedADHDherbswererespectivelyAcoriTatarinowiiRhizome，PolygalaeRadix，PreparedRehmanniaeRadix，OsDraconis，GlycyrrhizaeRadixetRhizome，Poria，ConchaOstreae，TestudinisCarapacisetPlastri，PaeoniaeAlbaRadix，SchisandraeFructusChinensis，FructusCorni，DioscoreaeRhizoma.ThetopseventypesoffrequentlyappliedADHDherbsbyeffectwererespectivelytonicherb，sedativeherbs，liver-windcalmingherbs，heatclearingherbs，astringentherbs，awakingherbsanddampclearinganddiuresispromotingherbs.Thetopthreepropertieswerewarm，coldandneutral，withwarmasthedominance.Thetopthreetastesweresweetness，bitternessandacridity，withsweetnessasthedominance.Thetopthreemeridianentrieswerelivermeridian，heartmeridianandkidneymeridian.Theassociationrulesanalysisshowedcommonlyusedherbalpairs.PolygalaeRadix-AcoriTatarinowiiRhizome，ConchaOstreae-OsDraconis，PreparedRehmanniaeRadix-FructusCorni-OsDraconis.Eighthighlyfrequentclusterprescriptionsweresummarizedbasedontheclusteranalysis.ThisstudyindicatesthatbasicTCMprescriptionsfortreatingADHDwereprincipallycomposedoftonics(nourishingliverandkidney，invigoratingheartandspleen)andtranquilization，whichweresupplementedwithherbsforcalmingliver，clearingheat，promotingqi-circulation，promotingblood-circulation，reducingphlegmandcalmingendogenouswind.ThecombinationofmultipledataminingtechniquescanreflecttheclinicalmedicationregularityofherbsfortreatingADHDinanoverallandobjectivemanner., 百拇医药(倪新强 韩新民 尹东奇 刘成全)
[关键词]注意力缺陷多动障碍;用药规律;数据挖掘;频数分析;关联规则;聚类分析
, 百拇医药
StudyonmedicationregularityoftraditionalChinesemedicinesintreating
attentiondeficithyperactivitydisorderbasedondatamining
NIXin-qiang/1，HANXin-min1*，YINDong-qi/1，LIUCheng-quan/1
(1.FirstClinicalMedicineCollege，NanjingUniversityofTraditionalChineseMedicine，Nanjing210046，China;
2.DepartmentofTraditionalChineseMedicine，Huai′anMaternalandChildHealthCareHospital，Huai′an223002，China)
, 百拇医药
[Abstract]Inthisstudy，effortsweremadetocollect88traditionalChinesemedicine(TCM)prescriptionsfortreatingADHDfrompublicliteratures，establishamedicationdatabaseandconductdataminingontheefficacy，properties，tastes，meridianentriesandcompatibilityregularityofTCMsbyusingfrequencyanalysis，associationrulesanalysisandclusteranalysis.Theresultsshowed33herbswithahighfrequency(≥10%).Thetop12frequentlyappliedADHDherbswererespectivelyAcoriTatarinowiiRhizome，PolygalaeRadix，PreparedRehmanniaeRadix，OsDraconis，GlycyrrhizaeRadixetRhizome，Poria，ConchaOstreae，TestudinisCarapacisetPlastri，PaeoniaeAlbaRadix，SchisandraeFructusChinensis，FructusCorni，DioscoreaeRhizoma.ThetopseventypesoffrequentlyappliedADHDherbsbyeffectwererespectivelytonicherb，sedativeherbs，liver-windcalmingherbs，heatclearingherbs，astringentherbs，awakingherbsanddampclearinganddiuresispromotingherbs.Thetopthreepropertieswerewarm，coldandneutral，withwarmasthedominance.Thetopthreetastesweresweetness，bitternessandacridity，withsweetnessasthedominance.Thetopthreemeridianentrieswerelivermeridian，heartmeridianandkidneymeridian.Theassociationrulesanalysisshowedcommonlyusedherbalpairs.PolygalaeRadix-AcoriTatarinowiiRhizome，ConchaOstreae-OsDraconis，PreparedRehmanniaeRadix-FructusCorni-OsDraconis.Eighthighlyfrequentclusterprescriptionsweresummarizedbasedontheclusteranalysis.ThisstudyindicatesthatbasicTCMprescriptionsfortreatingADHDwereprincipallycomposedoftonics(nourishingliverandkidney，invigoratingheartandspleen)andtranquilization，whichweresupplementedwithherbsforcalmingliver，clearingheat，promotingqi-circulation，promotingblood-circulation，reducingphlegmandcalmingendogenouswind.ThecombinationofmultipledataminingtechniquescanreflecttheclinicalmedicationregularityofherbsfortreatingADHDinanoverallandobjectivemanner., 百拇医药(倪新强 韩新民 尹东奇 刘成全)