[摘要] 细胞在生长增殖过程中受到內源或外源性的因素而使DNA结构发生变化或受损，如果不能在短时间内修复，将引起周期阻滞，甚至凋亡。利用肿瘤细胞快速增殖的特性，通过诱导其DNA损伤、细胞周期阻滞和凋亡已成为抗肿瘤药物研究的重要策略。研究显示，一些天然化合物可通过诱导肿瘤细胞DNA损伤抑制肿瘤细胞增殖，具有抗肿瘤药物研发价值。

    [关键词] 天然产物；DNA损伤；肿瘤细胞；周期阻滞；凋亡

    [Abstract] The DNA structures could be altered or even damaged by exogeous or endogenous factors during cell proliferation. Failure of effective and timely repair will lead to cell cycle arrest or apoptosis. By taking the advantage of the quick proliferation of cancer cells ......