基于中医传承辅助平台的现代中医药治疗心悸的用药规律分析(1)
[摘要]應用中医传承辅助平台(V25)软件，分析中国期刊全文数据库(CNKI)中通过中医药治疗心悸的组方用药规律，为进一步挖掘现代中医药治疗心悸及深度研发提供参考，以期更好的指导临床。搜集CNKI中关于现代中医药治疗心悸所载处方，完成中医传承辅助平台录入，建立中医药治疗心悸的方剂数据库，采用该软件集成的改进互信息法、复杂系统熵聚类等数据挖掘方法，对数据库所录药物使用频次及其高频药物的四气、五味、归经分布进行分析，明确核心用药及其应用特点，分析其处方规则及用药经验。整理出治疗心悸的545首方剂，涉及247味中药，通过分析，发现心悸处方中药物多为温热药性，心、脾二经所占药物比重较大，说明治疗以养心、健脾为主；发现用药频次居前的11味中药与常用药对用药模式中的高频药物完全一致，故认为这11味药即为核心用药；发现处方中核心用药组方为桂枝甘草龙骨牡蛎汤并演化出9首治疗心悸的新处方。客观呈现了心悸的处方用药规律，为指导临床提供了极为有效的借鉴。
[关键词]心悸； 中医传承辅助平台； 用药规律； 数据挖掘
, 百拇医药
Analysis on medication rules of modern traditional Chinese medicines in
treating palpitations based on traditional Chinese medicine
inheritance support system
SUN Zhixin1， ZHANG Panpan1， GAO Wulin1， DAI Guohua2*
(1 Shandong University of Traditional Chinese Medicine， Ji′nan 250014， China；
2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine， Ji′nan 250012， China)
, 百拇医药
[Abstract]To analyze the prescription and medication rules of Chinese medicines in the treatment of palpitations in the Chinese journal full text database(CNKI) by using traditional Chinese medicine inheritance system， and provide a reference for further research and development of modern traditional Chinese medicines(TCMs) in treatment of palpitations In order to give better guidance for clinical mediation， prescriptions used for treatment of palpitations in CNKI were collected， and then were input to the TCM inheritance support system for establishing a Chinese medicine prescription database for palpitations The software′s revised mutual information， complex system entropy clustering and other data mining methods were adopted to analyze the prescriptions according to the frequencies of herbs， "four natures"， "five flavors" and "meridians" of the highfrequency medicines in the database， identify the core herbs and application characteristics， and analyze the prescription rules and medication experience Totally， 545 prescriptions used for palpitation were included in this study and involved 247 Chinese herbs The analysis results showed that the herbs in prescriptions for palpitation mostly had the warm property， and the herbs in heart and spleen meridian accounted for a larger proportion， indicating that the treatment was mainly to nourish heart and strengthen spleen The top 11 herbs in usage frequency were consistent with the highfrequency medicines in medication patterns of common herbal pairs； therefore， we considered that these 11 herbs were the core herbs； the core herbal combination included Cassia Twig， Licorice， fossil fragments， Ostreae decoction， and evolved into 9 new prescriptions for treating palpitation Our results objectively presented the prescription and medication rules for treating palpitation and provided extremely effective guidance for the clinical therapy, 百拇医药(孙志新 张盼盼 高武霖 戴国华)
[关键词]心悸； 中医传承辅助平台； 用药规律； 数据挖掘
, 百拇医药
Analysis on medication rules of modern traditional Chinese medicines in
treating palpitations based on traditional Chinese medicine
inheritance support system
SUN Zhixin1， ZHANG Panpan1， GAO Wulin1， DAI Guohua2*
(1 Shandong University of Traditional Chinese Medicine， Ji′nan 250014， China；
2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine， Ji′nan 250012， China)
, 百拇医药
[Abstract]To analyze the prescription and medication rules of Chinese medicines in the treatment of palpitations in the Chinese journal full text database(CNKI) by using traditional Chinese medicine inheritance system， and provide a reference for further research and development of modern traditional Chinese medicines(TCMs) in treatment of palpitations In order to give better guidance for clinical mediation， prescriptions used for treatment of palpitations in CNKI were collected， and then were input to the TCM inheritance support system for establishing a Chinese medicine prescription database for palpitations The software′s revised mutual information， complex system entropy clustering and other data mining methods were adopted to analyze the prescriptions according to the frequencies of herbs， "four natures"， "five flavors" and "meridians" of the highfrequency medicines in the database， identify the core herbs and application characteristics， and analyze the prescription rules and medication experience Totally， 545 prescriptions used for palpitation were included in this study and involved 247 Chinese herbs The analysis results showed that the herbs in prescriptions for palpitation mostly had the warm property， and the herbs in heart and spleen meridian accounted for a larger proportion， indicating that the treatment was mainly to nourish heart and strengthen spleen The top 11 herbs in usage frequency were consistent with the highfrequency medicines in medication patterns of common herbal pairs； therefore， we considered that these 11 herbs were the core herbs； the core herbal combination included Cassia Twig， Licorice， fossil fragments， Ostreae decoction， and evolved into 9 new prescriptions for treating palpitation Our results objectively presented the prescription and medication rules for treating palpitation and provided extremely effective guidance for the clinical therapy, 百拇医药(孙志新 张盼盼 高武霖 戴国华)