阿萨伊对虚热和虚寒证大鼠的脂肪代谢、免疫物质和内分泌激素的影响(1)
[摘要] 研究阿萨伊对虚热证、虚寒证大鼠的脂肪代谢、免疫物质及内分泌激素水平变化。SD大鼠分为空白组、虚热模型组、虚热模型加黄柏组、虚热模型加阿萨伊高、低剂量组、虚寒模型组、虚寒模型加肉桂组、虚寒模型加阿萨伊高、低剂量组；采用每日肌肉注射地塞米松磷酸钠、氢化可的松琥珀酸钠1次、连续21 d的方法制备大鼠虚热模型、虚寒模型；通过比色法检测脂肪代谢(FFA，LPL，HL)指标变化以及免疫(IgG，IgM，C3，C4)指标变化；通过放免法检测内分泌激素(CORT，E2，T)指标变化。阿萨伊高剂量组能降低虚热证大鼠血清中FFA，LPL，HL值(P<0.01或P<0.001)；阿萨伊高剂量组能显著升高虚热证大鼠血清中IgG，IgM，C3值(P<0.05或P<0.001)；阿萨伊高剂量组能显著升高虚热证大鼠血清中CORT值(P<0.05)，能显著降低E2，E2/T值(P<0.05)；阿萨伊高剂量组对虚寒模型脂肪代谢指标作用不明显，但可以升高免疫指标IgG，IgM，C3值(P<0.05或P<0.001)，同时对内分泌激素指标CORT值也有升高的作用(P<0.05)。阿萨伊的作用趋向与黄柏一致，表现出对虚热模型大鼠的调整作用；与肉桂相反，对虚寒模型大鼠的指标纠正不明显。本实验从同类比较、异类反证角度验证了理论推导的阿萨伊中药寒凉药性。
, 百拇医药
[关键词] 阿萨伊；虚热证；虚寒证；脂肪代谢；免疫物质；内分泌激素；中药药性
[Abstract] To study the effects of Aaí (Euterpe oleracea) on lipid metabolism， immune substances and endocrine hormone level in rats with deficiency-heat and deficiency-cold syndrome. SD rats were divided into blank control group， deficiency-heat model group， deficiency-heat & Phellodendri Cortex group， deficiency-heat & Aaí high dose and low dose groups， deficiency-cold model group， deficiency-cold & Cinnamomi Cortex group， deficiency-cold & Aaí high dose and low dose groups. The rats received intramuscular injection of dexamethasone sodium phosphate (0.35 mg) or hydrocortisone sodium succinate (20 mg) for 21 days to set up deficiency-heat models and deficiency-cold models. Then the changes in fatmetabolism levels (FFA， LPL， HL) and immune indexes (IgG， IgM， C3 and C4) were detected by colorimeter；and the levels of endocrine hormone indexes (CORT， E2 and T) were detected by radioimmunoassay. The levels of FFA， LPL and HL in serum were reduced (P<0.01 or P<0.001)；levels of IgG， IgM and C3 in serum were increased (P<0.05 or P<0.001)；level of CORT in serum was increased (P<0.05) and the level of E2， E2/T in serum were reduced in the Aaí high dose group (P<0.05). The effect of high dose Aaí on fat metabolism was not obvious in deficiency-cold models， but the levels of IgG， IgM， C3 and CORT in serum were increased (P<0.05 or P<0.001). Aaí was showed the same effect trend with Phellodendri Cortex in adjusting the levels of deficiency-heat rats；but unlike Cinnamomi Cortex， Aaí was showed no obvious effect in adjusting the levels of deficiency-cold rats. In this experiment， homogeneous comparison and heterogeneous disproof were used to verify the cold nature of Aaí.
, 百拇医药
[Key words] Aaí；deficiency-heat；deficiency-cold；lipid metabolism；immune substances；endocrine hormone；Chinese herbal properties
阿薩伊(英文名：Aaí)在我国被称为巴西莓，一种产自南美的棕榈树Euterpe oleraceae Mart.的新鲜果实[1]，在巴西、秘鲁、哥伦比亚、苏里南等地广泛使用[2]，2013年由卫生部引入我国[3]。在古代，中医药是古丝绸之路商贸活动的重要内容。两晋南北朝时期，中医药传入朝鲜、日本、韩国，并逐步影响到东南亚诸国。隋唐五代、宋元时期，鉴真东渡日本，玄奘西行取经，加强了中医药与周边国家的交流。随后，乳香、没药、血竭等阿拉伯地区传统药物也随丝绸之路交流传入中国，丰富了本草学品种。如今在中医药现代化背景下，作为外来植物药的阿萨伊能否引入中药与我国现有中药进行配伍使用发挥医疗保健作用，尚需要进行理论及实验多方面的科学研究。, 百拇医药(王子晨 张建军 朱映黎 瞿研 费文婷 王莎 王景霞 王林元)
, 百拇医药
[关键词] 阿萨伊；虚热证；虚寒证；脂肪代谢；免疫物质；内分泌激素；中药药性
[Abstract] To study the effects of Aaí (Euterpe oleracea) on lipid metabolism， immune substances and endocrine hormone level in rats with deficiency-heat and deficiency-cold syndrome. SD rats were divided into blank control group， deficiency-heat model group， deficiency-heat & Phellodendri Cortex group， deficiency-heat & Aaí high dose and low dose groups， deficiency-cold model group， deficiency-cold & Cinnamomi Cortex group， deficiency-cold & Aaí high dose and low dose groups. The rats received intramuscular injection of dexamethasone sodium phosphate (0.35 mg) or hydrocortisone sodium succinate (20 mg) for 21 days to set up deficiency-heat models and deficiency-cold models. Then the changes in fatmetabolism levels (FFA， LPL， HL) and immune indexes (IgG， IgM， C3 and C4) were detected by colorimeter；and the levels of endocrine hormone indexes (CORT， E2 and T) were detected by radioimmunoassay. The levels of FFA， LPL and HL in serum were reduced (P<0.01 or P<0.001)；levels of IgG， IgM and C3 in serum were increased (P<0.05 or P<0.001)；level of CORT in serum was increased (P<0.05) and the level of E2， E2/T in serum were reduced in the Aaí high dose group (P<0.05). The effect of high dose Aaí on fat metabolism was not obvious in deficiency-cold models， but the levels of IgG， IgM， C3 and CORT in serum were increased (P<0.05 or P<0.001). Aaí was showed the same effect trend with Phellodendri Cortex in adjusting the levels of deficiency-heat rats；but unlike Cinnamomi Cortex， Aaí was showed no obvious effect in adjusting the levels of deficiency-cold rats. In this experiment， homogeneous comparison and heterogeneous disproof were used to verify the cold nature of Aaí.
, 百拇医药
[Key words] Aaí；deficiency-heat；deficiency-cold；lipid metabolism；immune substances；endocrine hormone；Chinese herbal properties
阿薩伊(英文名：Aaí)在我国被称为巴西莓，一种产自南美的棕榈树Euterpe oleraceae Mart.的新鲜果实[1]，在巴西、秘鲁、哥伦比亚、苏里南等地广泛使用[2]，2013年由卫生部引入我国[3]。在古代，中医药是古丝绸之路商贸活动的重要内容。两晋南北朝时期，中医药传入朝鲜、日本、韩国，并逐步影响到东南亚诸国。隋唐五代、宋元时期，鉴真东渡日本，玄奘西行取经，加强了中医药与周边国家的交流。随后，乳香、没药、血竭等阿拉伯地区传统药物也随丝绸之路交流传入中国，丰富了本草学品种。如今在中医药现代化背景下，作为外来植物药的阿萨伊能否引入中药与我国现有中药进行配伍使用发挥医疗保健作用，尚需要进行理论及实验多方面的科学研究。, 百拇医药(王子晨 张建军 朱映黎 瞿研 费文婷 王莎 王景霞 王林元)