[摘要] 中药现代化研究逐步成为世界性的潮流。反向对接技术也逐步成为中药现代化研究的有利工具，将一个小分子药物对接在一组临床相关大分子靶标的潜在结合腔中，通过对结合特征的详细分析，根据结合紧密程度对靶标进行排名，从而潜在地鉴定可能与其作用机制或副作用相关药物的新分子靶标。近年来，为了探索中药的作用机制、筛选中药有效成分以及寻找药物作用于疾病的靶点，反向分子对接技术被广泛运用并取得了瞩目的成绩。该研究通过文献综述，总结反向分子对接技术应用于中药作用靶点、有效成分筛选及中药潜在作用机制探索的情况，为中药临床研究及新药研发提供更多的理论依据。

    [关键词] 中药； 反向分子对接； 对接软件； 数据库

    [Abstract] Traditional Chinese medicine(TCM) modernization has gradually become a worldwide trend. Reverse docking technology has also gradually become a useful tool for TCM modernization. It involves docking a small-molecule drug in the potential binding cavities of a set of clinically relevant macromolecular targets. Detailed analysis of the binding characteristics was used for the ranking of the targets according to the tightness of binding. This process can be used to potentially identify the novel molecular targets for the drug which may be relevant to its mechanism of action or side effect.In order to explore the action mechanism ......