【摘要】Slug基因在多种恶性肿瘤中存在明显上调,Slug上调的肿瘤容易出现远处转移、较深的肿瘤浸润深度和较差的预后[1-2]。后来发现[3]Slug既能下调肿瘤细胞内E-cadherin表达,又能上调细胞内VEGF蛋白表达,因此,Slug与恶性肿瘤转移和血管生成有关。Hotz等[4]新近发现,胰腺癌组织及高转移潜能的胰腺癌细胞株存在Slug的明显上调。

    【关键词】Slug基因;胰腺癌;影响Target to Slug gene expression to vitro pancreatic gland cancer cell biology behavior influence

    Wang Ximan1 Zhuang Kelin2 Liu Yifei2 et al.

    【Abstract】The Slug gene has the obvious upward in many kinds of m alignant tumors, the Slug upward tumor easy to present the distant place shift, the deep tumor infiltration depth and bad prognosis[1-2] . Afterward discovered [3]Slug both to be able to decline in the tumour cell E-cadherin to express, and could surrender to the state in the cell the VEGF protein to express, therefore, Slug and the m alignant tumor shift and the blood vessel production concerned. Hotz and so on [4]recently discovered that the cancer of the pancreas organization and the high shift potential’s cancer of the pancreas cell line has Slug the obvious upward. ......