【摘 要】目的：观察托伐普坦联合左西孟旦对顽固性心力衰竭患者治疗效果的改善作用。方法：选取2018年1-12月122例顽固性心力衰竭患者，分实验组、对比组，实验组利用托伐普坦联合左西孟旦治疗，对比组左西孟旦单一用药，比较治疗效果。结果：实验组总有效率95.08%，对比组总有效率81.96%，两组心功能有统计学意义(P<0.05)。结论：顽固性心力衰竭在利用左西孟旦治疗基础上，加用托伐普坦治疗效果显著。

    【关键词】顽固性心力衰竭;托伐普坦;左西孟旦

    【中图分类号】R541.4 【文献标识码】A 【文章编号】1002-8714(2019)10-0034-01

    【Abstract】 Objective： To observe the effect of topiramate combined with levosimendan on the treatment of refractory heart failure. Methods： 122 patients with refractory heart failure from January to December 2018 were divided into experimental group and control group. The experimental group was treated with topiramate combined with levosimendan ......