七氟烷\异氟烷和恩氟烷在肝癌切除术中的应用(1)
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【摘要】 目的 观察七氟烷、异氟烷和恩氟烷全麻对肝癌切除术患者的影响。
方法将80例ASAⅠ~Ⅱ级择期行肝癌切除术的病人随机分为四组:七氟烷组(S1组)、异氟烷组(S2组)、恩氟烷组(S3 组)和对照丙泊酚组(P组),每组20例。S1、S2、S3组分别行七氟烷、异氟烷和恩氟烷吸入麻醉,P组行丙泊酚静脉麻醉。观察四组患者麻醉前(基础值)、诱导后、插管后1 min、5 min、10 min、切皮时、切皮后30 min、60 min、停药时、术毕、苏醒时、拔管时、拔管后1 min、5 min、10 min的MAP、HR。术后1 d、5 d、10 d、20 d抽取病人静脉血,测定谷丙转氨酶(ALT)、谷草转氨酶(AST)水平。结果 与基础值相比,四组在手术过程中,MAP、HR都有波动,但各组之间MAP无显著性差异(P>0.05),S2组HR较其他三组升高(P<0.05),但总体变化范围未超过±30%;与术前相比,术后四组患者的ALT、AST水平均有显著性差异(P<0.05或0.01),但各组相同时间点的ALT、AST水平均无显著性差异(P>0.05)。结论七氟烷、异氟烷和恩氟烷应用于肝癌切除术麻醉,效果满意。
【关键词】 七氟烷;异氟烷;恩氟烷;肝癌切除术
文章编号:1003-1383(2010)06-0656-03 中图分类号:R 614.2+7 文献标识码:A
doi:10.3969/j.issn.1003-1383.2010.06.002
The application of sevoflurane,isoflurane and enflurane in liver carcinoma hepatectomy
MA He,RUAN Lin
(Department of Anesthesiology,the Tumor Hospital of Guangxi Medical University,Nanning530021)
【Abstract】 Objective To observe the effect of sevoflurane, isoflurane and enflurane in treating patients with liver carcinoma hepatectomy.
Methods Eighty ASA Ⅰor Ⅱ patients undergoing elective liver carcinoma hepatectomy under general anesthesia were randomly allocated to one of four groups with 20 patients in each group:group S1,gave sevoflurane inhalation anesthesia;group S2,isoflurane;group S3,enflurane;group P,gave intravenous anesthesia of propofol.Observed the MAP、HR in all groups before hocus(baise values),after inducement, 1 min、5 min、10 min after trachea cannula and some other corresponding timepionts.The serum glutamicpyruvic transaminase and glutamicoxalacetic transaminase level were detected 1 d、5 d、10 d、20 d after the operation in all patients.
Results There was no significant difference between the four groups on MAP (P>0.05).Compared with that before the operation,there was significant difference in all four groups on serum ALT、AST level(P<0.05 or 0.01),but there was no sig
nificant difference between the four groups(P>0.05) .
Conclusion Sevoflurane,isoflurane and enflurane could be great help in liver carcinoma hepatectomy.
【Key words】sevoflurane;isoflurane;enflurane;liver carcinoma hepatectomy
全身麻醉中广泛应用吸入麻醉药,最常用的吸入麻醉药是卤族吸入麻醉药,主要包括氟烷、七氟烷、异氟烷、恩氟烷和地氟烷,它们有麻醉效能强,诱导、苏醒快,无燃烧、爆炸等优点。我国肝癌死亡率在部分城市中占恶性肿瘤死亡率的第二位,手术是主要治疗手段。肝癌手术麻醉除了满足手术要求,保证病人安全外,还要考虑减少麻醉对肝功能的损害 ......
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