高同型半胱氨酸血症与2型糖尿病乳酸酸中毒关系的探讨(1)
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【摘要】 目的 探讨高同型半胱氨酸血症与2型糖尿病(T2DM)乳酸酸中毒的关系。方法 选取100例T2DM患者,其中60例服用双胍类降糖药物(A组), 40例未服用双胍类降糖药物(B组),另择100例健康人作为对照组。抽血检测各组的血乳酸、糖化血红蛋白(HbA1c)、肌酐(Cr)、尿素氮(BUN)和同型半胱氨酸(Hcy)。结果 A组的乳酸水平为(25.12±5.09) mmol/L,而B组为(2.10±0.20) mmol/L,对照组的乳酸水平为(1.15±0.10)mmol/L,三组比较差异有统计学意义(F=1519.12,P=0.0000),进一步两两比较,A组的乳酸水平显著高于B组和对照组(均P<0.01),而B组乳酸水平和对照组比较差异无统计学意义(P>0.05)。三组Cr、BUN、Hcy和HbA1c的检测值比较差异均有统计学意义(P<0.01),其中A组、B组的Cr、BUN、Hcy和HbA1c检测值均显著高于对照组(P<0.01),A组的Cr、BUN和Hcy检测值显著高于B组(P<0.01)。Hcy与血乳酸水平呈正相关(r=0.997,P<0.01)。结论 高同型半胱氨酸血症是2型糖尿病乳酸酸中毒的一个重要危险因素。
【关键词】 高同型半胱氨酸血症;2型糖尿病;乳酸酸中毒
文章编号:1003-1383(2012)04-0471-02
中图分类号:R 587.1 文献标识码:A
doi:10.3969/j.issn.1003-1383.2012.04.0007
Discussion on the relationship of Hyperhomocysteinemia and type-2 diabetic mellitus lactic acidosis
YU Lihong1,Reziwanguli?Apaer2,GONG Yanxia3,TIAN Gang3
(1.General Medicine,Jixian People’s Hospital,Tianjin 301900;
2.Nephropathy Department,Kashi First People’s Hospital,Kashi 844000,Xinjiang;
3.Laboratory Department,Tianjin Public Security Hospital,Tianjin 300040)
[HJ*2][HJ]
【Abstract】 Objective To explore the relationship of Hyperhomocysteinemia and type-2 diabetic mellitus(T2DM) lactic acidosis.
Methods 100 cases with T2DM were divided into Group A (60 cases) and Group B (40 cases). Group A took Metformin for oral administration and Group B took no Metformin.100 healthy people were selected as the control group ......
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