半乳糖配体介导Cmyc反义锁核酸对肝癌细胞增殖和凋亡的影响(4)
[3]Chauhan A，Paul R，Debnath M，et al.Synthesis of fluorescent binaphthyl amines that bind cMYC Gquadruplex DNA and repress cMYC expression[J].J Med Chem，2016，59(15)：72757281.
[4]罗艳红，邓益斌，邹佳峻. 反基因锁核酸体外阻断肝癌细胞系乙肝病毒S基因表达[J].基础医学与临床，2014，14(2)：206210.
[5]Deng YB，Qin HJ，Luo YH，et al.Blocking the expression of hepatitis B virus S gene in hepatocellular carcinoma cell lines with anti gene locked nucleic acid in vitro[J].GENET MOL RES，2015，14(2)：54455451.
[6]Ho C，Wang C，Mattu S，et al.AKT(vakt murine thymoma viral oncogene homolog 1) and NRas(neuroblastoma ras viral oncogene homolog)coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR(mammalian target of rapamycin complex 1)，FOXM1(forkhead box M1)/SKP2，and Cmyc pathways[J].Hepatology，2012，55(3)：833845.
[7]Xiao W，Wang J，Ou C，et al.Mutual interaction between YAP and Cmyc is critical for carcinogenesis in liver cancer[J].Biochem Bioplys Res Commun，2013，439(2)：167172.
[8]Lin F，Ding R，Zhang S，et al.Decrease expression of microRNA744 promotes cell proliferation by targeting Cmyc in human hepatocellular carcinoma[J].Cancer Cell Int，2014，14：5860.
[9]蒋建伟，张洹.受体介导的Cmyc反义核酸抑制肝癌移植瘤生长[J].中国肿瘤临床，2006，33(22)：13071311.
(收稿日期：2016-11-17修回日期：2016-12-30)
A：空白对照组；B：无关序列组；c：未修饰寡核苷酸组；d：硫代寡核苷酸组；e：反义锁核酸组。
图3 各组肝細胞凋亡散点图, http://www.100md.com(肖树荣 邓益斌 许桂丹 黄赞松)
[4]罗艳红，邓益斌，邹佳峻. 反基因锁核酸体外阻断肝癌细胞系乙肝病毒S基因表达[J].基础医学与临床，2014，14(2)：206210.
[5]Deng YB，Qin HJ，Luo YH，et al.Blocking the expression of hepatitis B virus S gene in hepatocellular carcinoma cell lines with anti gene locked nucleic acid in vitro[J].GENET MOL RES，2015，14(2)：54455451.
[6]Ho C，Wang C，Mattu S，et al.AKT(vakt murine thymoma viral oncogene homolog 1) and NRas(neuroblastoma ras viral oncogene homolog)coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR(mammalian target of rapamycin complex 1)，FOXM1(forkhead box M1)/SKP2，and Cmyc pathways[J].Hepatology，2012，55(3)：833845.
[7]Xiao W，Wang J，Ou C，et al.Mutual interaction between YAP and Cmyc is critical for carcinogenesis in liver cancer[J].Biochem Bioplys Res Commun，2013，439(2)：167172.
[8]Lin F，Ding R，Zhang S，et al.Decrease expression of microRNA744 promotes cell proliferation by targeting Cmyc in human hepatocellular carcinoma[J].Cancer Cell Int，2014，14：5860.
[9]蒋建伟，张洹.受体介导的Cmyc反义核酸抑制肝癌移植瘤生长[J].中国肿瘤临床，2006，33(22)：13071311.
(收稿日期：2016-11-17修回日期：2016-12-30)
A：空白对照组；B：无关序列组；c：未修饰寡核苷酸组；d：硫代寡核苷酸组；e：反义锁核酸组。
图3 各组肝細胞凋亡散点图, http://www.100md.com(肖树荣 邓益斌 许桂丹 黄赞松)