ConclusionRegular monitoring for changes of indexes like Cys C，Hcy，β2MG and urine mAlb can help to understand the development of diabetic nephropathy patients，and its clinical value is better than that of single observation index.Thus， it is worthy of popularization and application.

    【Key words】Cys C；Hcy；β2MG；mAlb；DN

    根据国际糖尿病联盟(IDF)的最新统计数据显示，我国糖尿病患者已高达1.14亿，居世界首位。糖尿病肾病(diabetic nephropathy，DN)是糖尿病发展过程中导致的终末期病变，是2型糖尿病(T2DM)最常见的严重并发症 ......