枸橼酸咖啡因与氨茶碱防治早产极低出生体重儿呼吸暂停的临床疗效对比(2)
ConclusionCaffeine citrate administered at load dose of 20 mg/(kg·d) and maintenance dose of 10 mg/(kg·d)until 1 week of cessation of apnea has better effect and safety than aminophylline in early prevention and treatment of apnea in very low birth weight infants.【Key words】caffeine citrate；aminophylline；premature children；apnea；early prevention and treatment
早产儿呼吸暂停(apnea of prematurity，AOP)主要指原发性呼吸暂停，定义为呼吸停止20 s伴有心率减慢<100 次/min，或临床表现为青紫、血氧饱和度降低及四肢肌张力低下[1]。有研究报道，孕周小于28周、30～32周的早产儿呼吸暂停发生率分别为90%、50% ......
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