性激素与老年男性冠心病患者冠状动脉狭窄程度的关系(1)
【摘要】目的观察老年男性冠心病患者性激素，包括雌二醇(E2)、睾酮(T)、孕酮(P)及E2/T的水平，探讨性激素与冠状动脉血管狭窄程度的相关性。
方法收集接受冠状动脉造影检查并诊断为冠心病的老年男性患者164 例，根据冠状动脉狭窄的Gensini评分结果将入选患者分为低分组(n=89)和高分组(n=75)，分析性激素水平的变化及与Gensini评分的关系。
结果老年男性冠心病患者高分组的E2/T高于低分组(P<0.05)，T水平低于低分组水平(P<0.05)； T水平的降低、E2/T水平的升高是高冠脉Gensini评分的独立危险因素；在老年男性冠心病患者中，T水平与Gensini评分具有负相关性(r=-0.562)，E2/T水平与Gensini评分具有正相关性(r=0.676)。
结论老年男性冠心病患者的T和E2/T水平与冠状动脉狭窄具有相关性，两者对病情严重程度具有提示意义。
【关键词】性激素；老年；男性；冠心病；狭窄程度
中图分类号：R541.4文献标识码：ADOI：10.3969/j.issn.10031383.2017.05.011
Relationship between sex hormone and the degree of coronarystenosis in elderly male patients with coronary heart disease
[HJ2][HJ]
Zhao Hui，SU Yi，Ma Xin
(Department of Cardiovascular Medicine One，Jiaozuo Second People’s Hospital，Jiaozuo 454000，China)
[HJ2][HJ]
【Abstract】ObjectiveTo observe the changes of sex hormones included estradiol(E2)，testosterone(T)，progesterone (P) and E2/T in elderly male patients with coronary heart disease，and to analyze relationship between sex hormones and the degree of coronary stenosis.
Methods164 elderly male patients who underwent coronary angiography and diagnosed with coronary artery disease were collected，and the collected patients were divided into low score group(n=89)and high score group(n=75)on the basis of Gensini scores of coronary stenosis.Then，the relationship between the changes of sex hormones and Gensini scores were analyzed.
ResultsThe E2/T level in the high score group was higher than that of the low score group(P<0.05)，but the T level was lower than that of the low score group(P<0.05).The decrease of T level and increase of E2/T level were independent risk factors for high coronary Gensini score.In elderly male patients with coronary heart disease，T level was negatively correlated with Gensini score(-0.562)，but E2/T level and Gensini score had a positive correlation(r=0.676).
ConclusionT and E2/T level of elderly male patients are related to coronary artery stenosis，and both of them have important implications for the severity of the disease.
【Key words】sex hormones；the elderly；male；coronary heart disease；degree of coronary stenosis
随着生活方式的改变和人民生活水平的日益提高，冠心病(CHD)成为老年男性的主要死因[1]，并受到广泛关注。目前已研究证实性别是冠心病的高危因素之一，绝经前女性CHD的发生率明显低于同龄的男性，而绝经后女性CHD的发生率并不低于同龄男性[2]。提示性激素在冠心病的发生发展中有着十分重要的作用。本研究通过测定老年男性冠心病患者性激素，包括雌二醇(E2)、睾酮(T)、孕酮(P)及E2/T的水平，结合冠状动脉造影结果，探讨性激素与冠状动脉狭窄程度的关系。
1资料与方法
1.1研究对象
选择2015年12月至2016年12月在我院心内科接受冠状动脉造影检查并诊断为冠心病的老年男性患者164 例。冠心病诊断标准：根据患者症状、体征、心电图及心肌酶检查，并经冠状动脉造影(CAG)确诊。CAG结果提示至少1支冠状动脉狭窄≥50%者诊断为冠心病。排除感染、炎症、心衰、甲亢、肿瘤、免疫系统疾病、血液系统疾病、中重度肝肾功能不全等疾病。所有患者签署知情同意书。, http://www.100md.com(赵晖 苏毅 马欣)
方法收集接受冠状动脉造影检查并诊断为冠心病的老年男性患者164 例，根据冠状动脉狭窄的Gensini评分结果将入选患者分为低分组(n=89)和高分组(n=75)，分析性激素水平的变化及与Gensini评分的关系。
结果老年男性冠心病患者高分组的E2/T高于低分组(P<0.05)，T水平低于低分组水平(P<0.05)； T水平的降低、E2/T水平的升高是高冠脉Gensini评分的独立危险因素；在老年男性冠心病患者中，T水平与Gensini评分具有负相关性(r=-0.562)，E2/T水平与Gensini评分具有正相关性(r=0.676)。
结论老年男性冠心病患者的T和E2/T水平与冠状动脉狭窄具有相关性，两者对病情严重程度具有提示意义。
【关键词】性激素；老年；男性；冠心病；狭窄程度
中图分类号：R541.4文献标识码：ADOI：10.3969/j.issn.10031383.2017.05.011
Relationship between sex hormone and the degree of coronarystenosis in elderly male patients with coronary heart disease
[HJ2][HJ]
Zhao Hui，SU Yi，Ma Xin
(Department of Cardiovascular Medicine One，Jiaozuo Second People’s Hospital，Jiaozuo 454000，China)
[HJ2][HJ]
【Abstract】ObjectiveTo observe the changes of sex hormones included estradiol(E2)，testosterone(T)，progesterone (P) and E2/T in elderly male patients with coronary heart disease，and to analyze relationship between sex hormones and the degree of coronary stenosis.
Methods164 elderly male patients who underwent coronary angiography and diagnosed with coronary artery disease were collected，and the collected patients were divided into low score group(n=89)and high score group(n=75)on the basis of Gensini scores of coronary stenosis.Then，the relationship between the changes of sex hormones and Gensini scores were analyzed.
ResultsThe E2/T level in the high score group was higher than that of the low score group(P<0.05)，but the T level was lower than that of the low score group(P<0.05).The decrease of T level and increase of E2/T level were independent risk factors for high coronary Gensini score.In elderly male patients with coronary heart disease，T level was negatively correlated with Gensini score(-0.562)，but E2/T level and Gensini score had a positive correlation(r=0.676).
ConclusionT and E2/T level of elderly male patients are related to coronary artery stenosis，and both of them have important implications for the severity of the disease.
【Key words】sex hormones；the elderly；male；coronary heart disease；degree of coronary stenosis
随着生活方式的改变和人民生活水平的日益提高，冠心病(CHD)成为老年男性的主要死因[1]，并受到广泛关注。目前已研究证实性别是冠心病的高危因素之一，绝经前女性CHD的发生率明显低于同龄的男性，而绝经后女性CHD的发生率并不低于同龄男性[2]。提示性激素在冠心病的发生发展中有着十分重要的作用。本研究通过测定老年男性冠心病患者性激素，包括雌二醇(E2)、睾酮(T)、孕酮(P)及E2/T的水平，结合冠状动脉造影结果，探讨性激素与冠状动脉狭窄程度的关系。
1资料与方法
1.1研究对象
选择2015年12月至2016年12月在我院心内科接受冠状动脉造影检查并诊断为冠心病的老年男性患者164 例。冠心病诊断标准：根据患者症状、体征、心电图及心肌酶检查，并经冠状动脉造影(CAG)确诊。CAG结果提示至少1支冠状动脉狭窄≥50%者诊断为冠心病。排除感染、炎症、心衰、甲亢、肿瘤、免疫系统疾病、血液系统疾病、中重度肝肾功能不全等疾病。所有患者签署知情同意书。, http://www.100md.com(赵晖 苏毅 马欣)