布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床效果观察(1)
【摘要】目的观察布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床疗效。方法选择2016年3月至2017年5月收治的86例哮喘急性发作患儿，将其按抽签法分为两组。对照组43例采用沙丁胺醇雾化吸入治疗，在此基础上，观察组43例加用布地奈德雾化吸入治疗，比较两组临床疗效、症状消失时间、肺功能、不良反应。结果治疗后，对照组呼吸困难、咳嗽、哮鸣音消失时间较观察组长，总有效率、最大呼气流速峰值(PEF)、第1秒最大呼吸容积(FEV1)、用力肺活量(FVC)等肺功能指标水平均较观察组低，差异有统计学意义(P<0.05)；两组不良反应发生率相比，差异无统计学意义(P>0.05)。结论采用布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作可提高临床疗效，缩短症状消失时间，改善肺功能，且不良反应较少。
【关键词】儿童哮喘急性发作；布地奈德；沙丁胺醇；雾化吸入
中图分类号：R562.2+5文献标识码：ADOI：10.3969/j.issn.1003-1383.2018.05.016
【Abstract】ObjectiveTo observe the clinical effect of budesonide combined with salbutamol aerosol inhalation in the treatment of children with acute attack of bronchial asthma.Methods86 children with acute attack of bronchial asthma admitted to hospital from March 2016 to May 2017 were selected and divided into two groups by draw lots.Control group(n=43) were given salbutamol aerosol inhalation，and based on which observation group(n=43) were treated with budesonide aerosol inhalation.And then，clinical efficacy，disappearance time of symptoms，pulmonary function and adverse reactions were compared between the two groups.ResultsAfter treatment，the disappearance time of dyspnea，cough，wheezing rale in the control group was longer than that in the observation group.The total effective rate，and pulmonary function index levels like peak expiratory flow rate(PEF)，forced expiratory volume in 1 second(FEV1) and forced vital capacity(FVC) in the control group were lower than those in the observation group，difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).ConclusionBudesonide combined with salbutamol aerosol inhalation in the treatment of children with acute attack of bronchial asthma can increase clinical efficacy，shorten the time of symptom disappearance，improve lung function，and have few adverse reactions.
【Key words】children with acute attack of bronchial asthma；budesonide；salbutamol；aerosol inhalation
小兒哮喘是儿童时期常见的肺部疾病，临床症状多表现为呼吸困难、反复咳嗽，伴有气道高反应性。近年来该病患病率逐渐增加，且疾病反复发作，患者若得不到有效治疗，可损伤患儿肺功能，影响其生长发育[1～2]。目前沙丁胺醇是临床小儿哮喘的常用治疗药物，具有扩张支气管，改善肺部通气或换气功能，缓解临床症状的作用。但临床应用发现，其对气道炎症控制不佳，疗效不尽如人意[3～4]。布地奈德属于糖皮质激素，具有抗炎作用，可减少炎性因子释放，且经临床证实，在小儿哮喘急性发作期采用糖皮质激素联合雾化吸入治疗，可显著缓解临床症状，改善肺功能[5]。鉴于此，本研究将进一步观察采用布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床疗效，现报告如下。
1资料与方法
1.1一般资料选择我院2016年3月至2017年5月收治的86例哮喘急性发作患儿，经医学伦理委员会审核通过，将其按抽签法分为两组。观察组43例，其中男25例，女18例；年龄3～12岁，平均(7.15±2.01)岁；病程3～19个月，平均(10.65±2.54)个月。对照组43例，其中男24例，女19例；年龄3～13岁，平均(7.18±2.03)岁；病程3～18个月，平均(10.59±2.51)个月。两组一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张鲜蕊 刘淑玲 张雪冰)
【关键词】儿童哮喘急性发作；布地奈德；沙丁胺醇；雾化吸入
中图分类号：R562.2+5文献标识码：ADOI：10.3969/j.issn.1003-1383.2018.05.016
【Abstract】ObjectiveTo observe the clinical effect of budesonide combined with salbutamol aerosol inhalation in the treatment of children with acute attack of bronchial asthma.Methods86 children with acute attack of bronchial asthma admitted to hospital from March 2016 to May 2017 were selected and divided into two groups by draw lots.Control group(n=43) were given salbutamol aerosol inhalation，and based on which observation group(n=43) were treated with budesonide aerosol inhalation.And then，clinical efficacy，disappearance time of symptoms，pulmonary function and adverse reactions were compared between the two groups.ResultsAfter treatment，the disappearance time of dyspnea，cough，wheezing rale in the control group was longer than that in the observation group.The total effective rate，and pulmonary function index levels like peak expiratory flow rate(PEF)，forced expiratory volume in 1 second(FEV1) and forced vital capacity(FVC) in the control group were lower than those in the observation group，difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).ConclusionBudesonide combined with salbutamol aerosol inhalation in the treatment of children with acute attack of bronchial asthma can increase clinical efficacy，shorten the time of symptom disappearance，improve lung function，and have few adverse reactions.
【Key words】children with acute attack of bronchial asthma；budesonide；salbutamol；aerosol inhalation
小兒哮喘是儿童时期常见的肺部疾病，临床症状多表现为呼吸困难、反复咳嗽，伴有气道高反应性。近年来该病患病率逐渐增加，且疾病反复发作，患者若得不到有效治疗，可损伤患儿肺功能，影响其生长发育[1～2]。目前沙丁胺醇是临床小儿哮喘的常用治疗药物，具有扩张支气管，改善肺部通气或换气功能，缓解临床症状的作用。但临床应用发现，其对气道炎症控制不佳，疗效不尽如人意[3～4]。布地奈德属于糖皮质激素，具有抗炎作用，可减少炎性因子释放，且经临床证实，在小儿哮喘急性发作期采用糖皮质激素联合雾化吸入治疗，可显著缓解临床症状，改善肺功能[5]。鉴于此，本研究将进一步观察采用布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作的临床疗效，现报告如下。
1资料与方法
1.1一般资料选择我院2016年3月至2017年5月收治的86例哮喘急性发作患儿，经医学伦理委员会审核通过，将其按抽签法分为两组。观察组43例，其中男25例，女18例；年龄3～12岁，平均(7.15±2.01)岁；病程3～19个月，平均(10.65±2.54)个月。对照组43例，其中男24例，女19例；年龄3～13岁，平均(7.18±2.03)岁；病程3～18个月，平均(10.59±2.51)个月。两组一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张鲜蕊 刘淑玲 张雪冰)