陈春艳 刘小军 祁绍艳

    【摘要】?目的?探究高渗盐水与甘露醇联合治疗对重型颅脑损伤颅内压增高患者血清肌酐(Scr)水平及格拉斯哥昏迷量表(GCS)评分的影响。方法?采用随机数字表，将2014年1月～2019年1月86例重型颅脑损伤颅内压增高患者分为两组，各43例。两组均予以常规治疗，对照组在常规治疗基础上予以20%甘露醇治疗，观察组在对照组基础上联合3%高渗盐水治疗，均治疗7 d。对比两组颅内压(ICP)、平均动脉压(MAP)、脑灌注压(CPP)、GCS评分及Scr水平。结果?治疗7 d后，观察组ICP、MAP及CPP均低于对照组，血清Scr水平低于对照组，差异有统计学意义(P0.05)。结论?高渗盐水与甘露醇联合治疗可降低重型颅脑损伤颅内压增高患者的ICP水平，且对血清Scr影响更小，但对GCS评分改善并不明显。

    【关键词】?重型颅脑损伤;颅内压增高;甘露醇;高渗盐水;血清肌酐;格拉斯哥昏迷评分

    中图分类号：R651.1+5?文献标志码：A?DOI：10.3969/j.issn.1003-1383.2021.02.014

    【Abstract】?Objective?To investigate the effect of hypertonic saline combined with mannitol on serum creatinine (Scr) level and Glasgow coma scale (GCS) score in patients with increased intracranial pressure after severe head injury. Methods?86 patients with increased intracranial pressure after severe craniocerebral injury from January 2014 to January 2019 were divided into control group and observation group ......