胃癌前哨淋巴结活检研究进展(2)
3.3 提高胃癌分期的准确性,正确评估胃癌预后和指导术后辅助治疗。而胃癌前哨淋巴结检测的目标直接指向最可能发生转移的SLN,可反映整个区域淋巴结的转移状态,不但微创简单,而且准确可靠,不容易遗漏,尤其对提高病理分期准确性,正确评估其预后,确定术后辅助化疗具有重要临床意义。
3.4 促进胃癌微创外科的发展。传统手术要留下15厘米左右的刀口,而采用腹腔镜胃癌微创手术,则只需在病人腹部打5个直径约1厘米的小孔,以供光源、操作刀的进入。术后,病人疼痛大大减轻,身体恢复更快。此外,采用腹腔镜胃癌微创手术,还有以下优点:减少肿瘤的扩散,减少肠粘连等术后并发症,减少手术中出血风险等。腹腔镜胃癌手术尤其适合年纪较大、身体虚弱的病人。
腹腔镜微创手术的另一个重大功效:在没有腹腔镜之前,对于开刀后发现的晚期肿瘤,医生多半选择放弃手术,这不仅使病人身体受损,还增大了肿瘤感染、扩散的风险。而有了腹腔镜以后,只需在病人腹部打一个孔进行探查,看是否能够进行手术治疗。这样一来,不需开刀,病人身体不受损伤,医生还可以通过此孔注入肿瘤化疗药物。对于病理不明的手术,还可以利用腹腔镜取组织做活检。
, http://www.100md.com
由于胃部血管丰富、解剖层面多、淋巴结清扫难度大、吻合复杂等因素,腹腔镜胃癌微创手术难度大,技术要求高。可以说,腹腔镜胃癌微创手术代表了医院外科医疗技术的精湛水平。
需要提醒的是,作为一种治疗手段,腹腔镜微创手术并不适合所有胃癌的治疗。受医疗器械本身的限制,腹腔镜对早期胃部肿瘤有着显著的治疗效果,倘若肿瘤过大,还是需要做开刀手术的。
参考文献
[1]Kaibara N, Sumi K, Yonekawa M, et al. Does extensive dissection of lymph nodes improve the results of surgical treatment of Gastric cancer [J]. Am Surg,1990, 159:218.
[2]Kodoma Y, Sugimachi K, Soejima K, et al. Evaluation of extensive lymph node dissection for carcinoma of stomach [J]. World Surg,1981, 5:241.
, 百拇医药
[3]CushieriA, Weeden S, Field J, et al. Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial Surgical Co-operative Group [J]. BrJCancer,1999, 79(9-10):1522
[4]Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH-40: a new method for axillary lymph-node dissection in breast cancer [J]. Can J Surg,2000, 43(1):191.
[5]刘志文,王淑宝. 微粒子活性炭在胃癌治疗中的应用[J]. 国外医学肿瘤分册,1999, 10(26):298-300.
, http://www.100md.com
[6]Dijkstra B, Hill L, et al. The Value of sentinel node mapping for staging melanoma [J]. Ir med J,2001, 94(7):210-212.
[7]Sano T, katai H, Sasako M, et al. Gastric lymphography and detection of sentinel nodes [J], Recent Results Cancer Res, 2000, 157(2):253-258.
[8]张德,李继广,魏明.逆转录聚合酶链扩增与免疫组化在检测胃癌区域淋巴结微转移中的相关研究[J].放射免疫学杂志,2008, 21(3):253-255.
[9]Mori M, Mimori K, Inouc H, et al. Detection of cancer micro metastases in lymph nodes by reverse transcriptase chain reaction [J]. Cancer Res,1995, 55:3417
, 百拇医药
[10]Gervasoni JE, Taneja C, Churng MA, et al. Biologic and clinical significance of lymphadenectomy [J], Surg Clin North Am,2000, 80(6):1631-1637.
[11]Kitagawq Y, Fujii H, Mukai M, et al. Radio-guided sentinel node detection for gastric cancer [J]. Br J Surg May,2002, 89(5):604-608.
[12]平田工一,木神原宣,日临外医会志,1996, 57(10):2339-2349.
[13]Elias D, Lasser P, Duvillard P. The sentinel lymph node in carcinoma of the digestive tract [J]. Bull Cancer.2002, 89(6):593-598., http://www.100md.com(张煜 仝德峰 刘江文)
3.4 促进胃癌微创外科的发展。传统手术要留下15厘米左右的刀口,而采用腹腔镜胃癌微创手术,则只需在病人腹部打5个直径约1厘米的小孔,以供光源、操作刀的进入。术后,病人疼痛大大减轻,身体恢复更快。此外,采用腹腔镜胃癌微创手术,还有以下优点:减少肿瘤的扩散,减少肠粘连等术后并发症,减少手术中出血风险等。腹腔镜胃癌手术尤其适合年纪较大、身体虚弱的病人。
腹腔镜微创手术的另一个重大功效:在没有腹腔镜之前,对于开刀后发现的晚期肿瘤,医生多半选择放弃手术,这不仅使病人身体受损,还增大了肿瘤感染、扩散的风险。而有了腹腔镜以后,只需在病人腹部打一个孔进行探查,看是否能够进行手术治疗。这样一来,不需开刀,病人身体不受损伤,医生还可以通过此孔注入肿瘤化疗药物。对于病理不明的手术,还可以利用腹腔镜取组织做活检。
, http://www.100md.com
由于胃部血管丰富、解剖层面多、淋巴结清扫难度大、吻合复杂等因素,腹腔镜胃癌微创手术难度大,技术要求高。可以说,腹腔镜胃癌微创手术代表了医院外科医疗技术的精湛水平。
需要提醒的是,作为一种治疗手段,腹腔镜微创手术并不适合所有胃癌的治疗。受医疗器械本身的限制,腹腔镜对早期胃部肿瘤有着显著的治疗效果,倘若肿瘤过大,还是需要做开刀手术的。
参考文献
[1]Kaibara N, Sumi K, Yonekawa M, et al. Does extensive dissection of lymph nodes improve the results of surgical treatment of Gastric cancer [J]. Am Surg,1990, 159:218.
[2]Kodoma Y, Sugimachi K, Soejima K, et al. Evaluation of extensive lymph node dissection for carcinoma of stomach [J]. World Surg,1981, 5:241.
, 百拇医药
[3]CushieriA, Weeden S, Field J, et al. Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial Surgical Co-operative Group [J]. BrJCancer,1999, 79(9-10):1522
[4]Yokota T, Saito T, Narushima Y, et al. Lymph-node staining with activated carbon CH-40: a new method for axillary lymph-node dissection in breast cancer [J]. Can J Surg,2000, 43(1):191.
[5]刘志文,王淑宝. 微粒子活性炭在胃癌治疗中的应用[J]. 国外医学肿瘤分册,1999, 10(26):298-300.
, http://www.100md.com
[6]Dijkstra B, Hill L, et al. The Value of sentinel node mapping for staging melanoma [J]. Ir med J,2001, 94(7):210-212.
[7]Sano T, katai H, Sasako M, et al. Gastric lymphography and detection of sentinel nodes [J], Recent Results Cancer Res, 2000, 157(2):253-258.
[8]张德,李继广,魏明.逆转录聚合酶链扩增与免疫组化在检测胃癌区域淋巴结微转移中的相关研究[J].放射免疫学杂志,2008, 21(3):253-255.
[9]Mori M, Mimori K, Inouc H, et al. Detection of cancer micro metastases in lymph nodes by reverse transcriptase chain reaction [J]. Cancer Res,1995, 55:3417
, 百拇医药
[10]Gervasoni JE, Taneja C, Churng MA, et al. Biologic and clinical significance of lymphadenectomy [J], Surg Clin North Am,2000, 80(6):1631-1637.
[11]Kitagawq Y, Fujii H, Mukai M, et al. Radio-guided sentinel node detection for gastric cancer [J]. Br J Surg May,2002, 89(5):604-608.
[12]平田工一,木神原宣,日临外医会志,1996, 57(10):2339-2349.
[13]Elias D, Lasser P, Duvillard P. The sentinel lymph node in carcinoma of the digestive tract [J]. Bull Cancer.2002, 89(6):593-598., http://www.100md.com(张煜 仝德峰 刘江文)