【摘要】目的 探讨内蒙古呼市和包头地区大肠埃希菌感染及其耐药情况。 方法 收集两市2010年-2011年各1224例来源不同的大肠埃希菌菌株， K-B纸片法进行药敏试验，NCCLSI 2010版评价结果。结果 12种抗生素药物的耐药性分析显示，呼市地区头孢吡肟、哌拉西林、呋喃妥因、复方新诺明、头孢他啶的耐药率低于包头地区，包头地区左氧氟沙星的耐药率低于呼市地区，之间有显著性差异。结论 不同地区医院患者来源、抗生素使用情况不同，大肠埃希菌耐药性各有特点，制定相应病原菌谱及耐药谱对合理应用抗生素意义重大。

    【关键词】大肠埃希菌；抗菌药物；耐药分析

    【中图分类号】R556.5【文献标识码】A【文章编号】1004-5511(2012)06-0330-01

    【Objective】 To investigate the antibiotic resistance of Escherichia coli and drug resistance from the Inner Mongolia Hohhot and Baotou region. Methods Antimicrobial susceptibility testing was performed with Kirby-Bauer method. A total of 1224 clinical strains of Escherichia coli were collected from 2010 to 2011 .The results were analyzed according to NCCLSI 2010 standard. Results 12 kinds of antibiotic drug resistance analysis showed that the Hohhot region, cefepime, piperacillin, nitrofurantoin, cotrimoxazole, ceftazidime resistance rates below the header area, Baotou levofloxacin of resistancerate lower than the Hohhot region, between the significant difference. Conclusion Resistance surveillance should be paid more attention, and effective measures should be adopted to prevent and control the resistant strains earlier. And it is necessary to monitor the Corresponding bacterial spectrum and resistance patterns of the reasonable use of antibiotics. ......