唾液酸化的神经细胞黏附因子在脑中可塑性的作用(1)
【摘要】 细胞粘附系统被认为是将基本遗传信息转换成三维蛋白质的分子模式。在众多细胞粘附分子中，NCAM是在神经系统中分布最广的，被研究最全面的细胞粘附因子。NCAM是一种糖蛋白，其功能与PSA有重要关系。通过选择性剪切及后修饰主要亚型有180，140，120KDa。其N末端晶体学研究表明嗜同种的识别和粘连通过一个NCAM的Ig1及Ig2两个区域与相对应分子形成反向平行的二聚体而产生。当NCAM唾液酸化后，由于多唾液酸有很大的疏水区及高的密度的负电荷，会减弱NCAM的粘合力，从而起到负向调节细胞信号传导的作用。【关键词】 唾液酸化；神经细胞黏附因子；脑中可塑性；作用
Sialyl the neural cell adhesion factor in the role of brain plasticity
GUOZiyuan ZENGLinfei
【Abstract】Cell adhesion system is considered the basic genetic information will be converted into three-dimensional model of protein molecules. Among the various cell adhesion molecules in, NCAM in the nervous system in the most widely distributed, was the most comprehensive study of cell adhesion factor. NCAM is a glycoprotein, which functions with the PSA has an important relationship. Shear through the selective and modified after the major subtypes are 180,140,120 KDa. Its N-terminal crystal studies show the same kind of recognition and adhesion through a NCAM Ig1 and Ig2 the two regions with the corresponding elements of a reverse parallel dimer arising. When NCAM sialyl, due to a lot of sialic acid drainage areas and the high density of negative charge, will weaken the bonding of NCAM, a negative adjustment to the role of signal transduction. ......
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