血浆雌激素和一氧化氮相关检验指标对围绝经期女性高血压患者的影响(1)
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[摘要]目的探索围绝经期女性高血压患者在夏冬两季血压变化与雌激素(E2)、一氧化氮(NO)等之间的相关性。方法观察组(I组)选择围绝经期女性高血压患者100例，对照组(II组)围经期健康妇女100例，夏冬两季检测患者血压(BP)、雌激素(E2)、一氧化氮(NO)、纤维蛋白原(F)、血小板(PLT)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平，分析各组参数之间差异，用Logistic回归分析筛选影响高血压的主要因素。结果在绝经前后I、II组E2水平均有极显著降低(p<0.01), 绝经前E2水平I组显著低于II组(0.010.05)，I、II组的夏季NO显著均高于冬季NO(p<0.01),夏季LDL均显著低于冬季LDL(p<0.01)。Logistic回归分析表明在上述诸因素中NO、E2、HDL是高血压的保护因素，F和LDL 是促进因素，PLT作用不显著。结论绝经后高血压保护性因素E2、NO、HDL水平均显著降低。而绝经后高血压组的促进因素LDL显著升高，冬季高血压患者血清纤维蛋白原浓度显著升高。证实外源性雌激素对女性高血压患者有保护作用。
关键词：高血压围绝经期雌激素一氧化氮
Study of estradiol and nitric oxide disorder in perimenopause women with hypertension
Liu Yingping1,ChenWei1, Shen jianmin2 et al.
(1 Department of Cardiovascular Disease, Beijing Shijitan Hospital,100038, 2 HanDan Railway Hospital,056001, 3. Beijing Fengtai Hospital, 100070).
【Abstract】Objective :To study the disorder of estrogen(E2) and nitric oxide(NO) in perimenopause women with hypertension. Methods : 100 perimenopause women with hypertension (group I) and 100, without hypertension (group II) were selected to compare the serum levels of E2,NO,Fibrinogen(F), Platelet Count(PLT), HDL,LDL. Measurements were performed every once in summer and winter. Results :There is sharpreduction( p < 0.01)of serum E2levelfrom pre-menopause to post-menopause in 2 groups. The serum E2 level is lower in group I than in group II during pre-menopause, and during post-menopause, there is no difference significantly (p > 0.05). Whether between pre and post-menopause or between group I and II, The differences ofNO serum level are significant(p < 0.01). HDL level is lower in group I than in group II during pre-menopause, and there is no difference during post-menopause between 2 groups. There is significant difference of LDL level between pre-menopause and post-menopause in-group I. There is significant difference of fibrinogen between 2 groups during post-menopause ......
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