小儿急性特发性血小板减少性紫癜的诊治(2)
5.5血小板输注由于急性ITP病儿血循环中含有大量抗血小板抗体与PA-IgG,输入的血小板很快被破坏,而且反复输注血小板悬液可产生血小板抗体,因此一般患儿不主张输注血小板。但如果外周血血小板计数<10×109/L,有严重出血或有危及生命的颅内出血或急性内脏出血倾向需紧急处理的患儿,可采用输注血小板治疗,但输注血小板的同时应给予大剂量肾上腺皮质激素、免疫球蛋白或其他免疫抑制剂。输入血小板数1.0×1011个/m2可提高血小板(5-10)×109/L,人工采血小板按10u/m2/次,须在采集后6小时内输注;机采血小板按1u/m2/次,机采血小板虽保存期3-5d,但输注过程应在半小时内完成。
参考文献
[1]贾苍松,胡莎.特发性血小板减少性紫癜及其诊断和治疗.中国实用儿科杂志,2009,24(10):814-816.
[2]黄绍良.小儿血液病临床手册[M].北京:人民卫生出版社,2000:742-750.
[3]Carcao MD,Zipursky A,Butchart S,et al.Shortcourse oral p rednisone therapy in children p resentingwith acute immune thrombocytopenic purpura(immune thrombocytopenic purpura)[J].Acta Paediatr,1998,424(1):71-74.
[4]Cooper N,Heddle NM,Haas de M,et al.Intravenous(IV)anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms:modulation of cytokine and platelet responses to IV anti-D by FcgRIIa and FcgRIIIa polymorphisms.Br J Haematol,2004,124:511-518.
[5]Scaradavou A,Woo B,Woloski BMR,et al.Intravenous anti-D treatment of immune thrombocytopenic purpura:experience in 272 patients.Blood,1997,89:2689-2700., 百拇医药(于爽)
参考文献
[1]贾苍松,胡莎.特发性血小板减少性紫癜及其诊断和治疗.中国实用儿科杂志,2009,24(10):814-816.
[2]黄绍良.小儿血液病临床手册[M].北京:人民卫生出版社,2000:742-750.
[3]Carcao MD,Zipursky A,Butchart S,et al.Shortcourse oral p rednisone therapy in children p resentingwith acute immune thrombocytopenic purpura(immune thrombocytopenic purpura)[J].Acta Paediatr,1998,424(1):71-74.
[4]Cooper N,Heddle NM,Haas de M,et al.Intravenous(IV)anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms:modulation of cytokine and platelet responses to IV anti-D by FcgRIIa and FcgRIIIa polymorphisms.Br J Haematol,2004,124:511-518.
[5]Scaradavou A,Woo B,Woloski BMR,et al.Intravenous anti-D treatment of immune thrombocytopenic purpura:experience in 272 patients.Blood,1997,89:2689-2700., 百拇医药(于爽)