免疫三氧联合氧化苦参碱治疗慢性乙性肝炎肝纤维化的疗效观察及护理
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【摘 要】目的：探讨免疫三氧联合氧化苦参碱治疗慢性乙肝肝纤维化临床疗效。方法：将155例CHB分为3组：均给予维生素类，葡醛内酯片，硫普罗宁0.3静滴或0.2，3次/日口服基础治疗。治疗组55例，在基础治疗基础上，给予氧化苦参碱600mg静脉点滴1次/日或口服0.2，3次/日及免疫三氧治疗，包括自体血液回输法(AHT)加直肠注气法(R I)。冲击疗程8周，每周3次AHT+R I，治疗剂量：AHT 25ug/ml,100m l血液，气血比例1：1；R I 10ug/ml，共300ml气体。巩固疗程16周，每周2次AHT+R I，治疗剂量：AHT 25ug/ml,100ml血液,气血比例1：1；R I 10ug/ml，共300ml气体。疗程6个月.。氧化苦参碱组50例，亦在基础治疗基础上，给予氧化苦参碱600mg静脉点滴1次/日或口服0.2，3次/日； 疗程6个月。对照组50例，单纯给予基础治疗 疗程6个月。观察患者透明质酸(HA)Ⅲ型胶原(PC-Ⅲ)Ⅳ胶原(PC-Ⅳ)的水平及肝功能变化。结果：治疗组ALT ALP TBIL HA PC-Ⅲ PC-Ⅳ有显著降低，与氧化苦参碱组、对照组比较，有显著差异(P<0.05或P<0.01)；而A/G则表现显著升高，与氧化苦参碱组、对照组比较亦有显著差异(P<0.05或P<0.01)。结论：免疫三氧提高氧化苦参碱抗肝纤维化作用，促进肝细胞恢复，保护肝脏。在治疗过程中严格无菌操作和三查七对，加强心理护理，严密观察病情变化，严格有效剂量是免疫三氧治疗取得疗效的保证。
【关键词】免疫三氧；氧化苦参碱；慢性乙型肝炎；肝纤维化；护理
【中图分类号】R 473.5 【文献标识码】A 【文章编号】1004- 7484(2012)04- 0074- 02
【Abstract】Objective：Study the clinical study of immune ozone and oxymatrine’s treatment for chronic hepatitis B hepatic fibrosis. Methods：155 cases are divided into 3 groups, which are generally offered vitamins, glucurolactone, tiopronin( 0.3g intravenous drip or 0.2g three times a day). The treatment group of 55 cases are offered oxymatrine 600mg intravenous drip or 0.2g taken orally three times a day and immune ozone treatment, including ART( antoblood refusion therapy ) and RI ( rectum insufflation ) based on the general treatment. Stosstherapy duration is 4 weeks, 3 times of ART and RI every week, with therapy dose AHT 25μg/ml, 100ml blood, OI and blood Rto 1:1, RI 10μg/ml, 300ml gas. The consolidating therapy duration is 8 weeks, 2 times of ART and RI every week, with therapy dose: ART 25μg/ml, 100ml blood, QI and blood Rto 1:1, RI 10μg/ml, 300ml gas. The duration is 6 months. The oxymatrine group of 50 cases are offered oxymatrine 600mg intravenous drip or 0.2g taken orally three times one day based on the general treatment. The duration is 6 months. The control group of 50 cases are received general treatment only ......
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