IGFBP5在神经管发育中的表达差异(2)
目前虽然对IGFBP5基因研究较多，但对其具体作用机制尚不明确，如IGFBP5作用的时间节点、作用途径；IGFBP5在脑发育过程中的变化及对神经发育的影响细节等，需进一步研究，参考文献：
[1] Harris MJ， Juriloff DM. Mini-review： toward understanding mechanisms of genetic neural tube defects in mice[J]. Teratology. 1999；60(5)：292-305.
[2] Klootwijk R， Schijvenaars MM， Mariman EC， et al. Further characterization of the genetic defect of the Bent tail mouse， a mouse model for human neural tube defects[J]. Birth Defects Res A Clin Mol Teratol. 2004；70(11)：880-884.
[3] 蒋立坚， 赖仁发， 李卫国等。基因芯片筛选成釉细胞瘤差异表达基因的研究[J]。中国病理生理杂志。2008；24(5)：992-996.
[4] Valentinis B， Baserga R. IGF-I receptor signalling in transformation and differentiation[J]. Mol Pathol. 2001；54(3)：133-137.
[5] Bondy C， Lee WH. Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development[J]. J Neurosci. 1993；13(12)：5092-5104.
[6] Beattie J， Allan GJ， Lochrie JD， et al. Insulin like growth factor binding protein5 (IGFBP5)： a critical member of the IGF axis [J]. Biochem J， 2006；395(1)：1-19.
[7] Miyatake T， Ueda Y， Nakashima R， et a1.Downregulation of insulin like growth factor binding protein5 (IGFBP5)：novel marker for cervical carcinogenesis [J]. Int J Cancer， 2007；120(10)： 2068-2077.
[8] Butt A J， Dickson K A， Jambazov S， et al. Enhancement of tumor necrosis factoralphainduced growth inhibition by insulinlike growth factorbinding protein5 (IGFBP5)， but not IGFBP3 in human breast cancer cells [J]. Endocrinology， 2005； 146(7)：3113-3122., 百拇医药(李新军等)
[1] Harris MJ， Juriloff DM. Mini-review： toward understanding mechanisms of genetic neural tube defects in mice[J]. Teratology. 1999；60(5)：292-305.
[2] Klootwijk R， Schijvenaars MM， Mariman EC， et al. Further characterization of the genetic defect of the Bent tail mouse， a mouse model for human neural tube defects[J]. Birth Defects Res A Clin Mol Teratol. 2004；70(11)：880-884.
[3] 蒋立坚， 赖仁发， 李卫国等。基因芯片筛选成釉细胞瘤差异表达基因的研究[J]。中国病理生理杂志。2008；24(5)：992-996.
[4] Valentinis B， Baserga R. IGF-I receptor signalling in transformation and differentiation[J]. Mol Pathol. 2001；54(3)：133-137.
[5] Bondy C， Lee WH. Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development[J]. J Neurosci. 1993；13(12)：5092-5104.
[6] Beattie J， Allan GJ， Lochrie JD， et al. Insulin like growth factor binding protein5 (IGFBP5)： a critical member of the IGF axis [J]. Biochem J， 2006；395(1)：1-19.
[7] Miyatake T， Ueda Y， Nakashima R， et a1.Downregulation of insulin like growth factor binding protein5 (IGFBP5)：novel marker for cervical carcinogenesis [J]. Int J Cancer， 2007；120(10)： 2068-2077.
[8] Butt A J， Dickson K A， Jambazov S， et al. Enhancement of tumor necrosis factoralphainduced growth inhibition by insulinlike growth factorbinding protein5 (IGFBP5)， but not IGFBP3 in human breast cancer cells [J]. Endocrinology， 2005； 146(7)：3113-3122., 百拇医药(李新军等)