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P53、β—catenin和HER—2在结直肠癌中的表达及临床意义(2)
http://www.100md.com 2014年5月1日 李明
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     综上所述,检测结直肠癌组织中P53、β-catenin、HER-2的表达,有助于指导结直肠癌治疗及预后评估,并为开发抗肿瘤新药,寻求靶向基因治疗提高临床证据。

    参考文献:

    [1] Jemal A, Bray F, Melissa M et al. Global cancer statistics [J]. CA Cancer J for Clin, 2011, 61(2):69-90.

    [2] Maruyama K, Ochiai A, Akimoto S, et al. Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer[J]. Oncology, 2000, 59(4):302-309.

    [3] Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in com-bination with chemotherapy versus chemotherapy alone for treat-ment of HER2 positive advanced gastric or gastro-oesophageal junction cancer( ToGA): a phase3, open – label, randomised con-trolled trial[J]. Lancet, 2010, 376( 9742): 687-697.

    [4] Park DI, Kang MS, Oh SJ, et al. HER-2/neu over-expression is an independent prognostic factor in colorectal cancer [J]. Int J Colorectal Dis, 2007, 22(5):491-497.

    [5] Doucas H, Garcea G, Neal CP, et al. Changes in the Wnt signaling pathway in gastro-intestinal cancer and their prognostic significance[J]. Eur J Cancer, 2005, 41(3):365-379.

    [6] Machado-Silva A, Perrier S, Bourdon JC. P53 family members in cancer diagnosis and treatment[J]. Semin Cancer Biol,2010,20(1):57-62.

    

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