【摘 要】目的：评价多西环素、沙利度胺联合多西环素治疗硬结型、囊肿型痤疮的临床疗效及安全性。方法：按照纳入标准选择70名硬结型、囊肿型患者，随机分为对照组(仅用多西环素)和治疗组(多西环素联合沙利度胺)、开放对照、定期观察。结果：治疗3周两组的有效率无统计学意义差异(P>0.05)，治疗8周后，两组的有效率分别为54.3%和82.9%，有统计学差异(P<0.05)。结论：沙利度胺联合多西环素治疗硬结型、囊肿型痤疮的疗效优于单一服用多西环素，未出现严重的副反应。

    【关键词】痤疮；沙利度胺，多西环素

    【中图分类号】R758.734 【文獻标识码】A 【文章编号】1004-7484(2019)01-0079-02

    Clinical observation of combination therapy with doxycycline and Thalidomide in the treatment of indurate and cystic acne

    【Abstract】Objective： To evaluate the efficacy and safety of combination therapy with doxycycline and Thalidomide in the treatment of indurate and cystic acne. Methods： Seventy patients were randomized into two groups： treatment group(n=35) and control group(n=35).The control group was treated with doxycycline ......