阿奇霉素对立克次体性心肌炎患者血清HMGB1和IFN—γ的影响(2)
另外,实验过程中分别检测A、B、C三组HMGB1、IFN-γ水平,发现HMGB1、IFN-γ浓度逐渐减弱,说明静滴阿奇霉素较口服使用可以更有效抑制其炎症反应,同时为使用阿奇霉素治疗立克次体性心肌炎提供了新证据,其理论依据为临床治疗立克次体性炎性并发症提供了新思路。
参考文献
[1] Kar A,Dhanaraj M,Dedeepiya D,et al. Acute encephalitis syndrome following scrub typhus infection [J].Indian J Crit Care Med,2014,18(7):453-455.
[2] 陈灏珠,钟南山,陆再英,等.内科学[M].第8版.北京:人民卫生出版社,2013:282-284.
[3] Griffith M,Peter JV,Karthik G,et al.Profile of organ dysfunction and predictors of mortality in severe scrub typhus infection requiring intensive care admission.[J].Indian J Crit Care Med,2014,18(8):497-502.
[4] Keller CA,Hauptmann M,Kolbaum J,et al.Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus.[J].PLoS Negl Trop Dis,2014,8(8):30-64.
[5] Singh R,Singh SP,Ahmad N.et al.A Study of Etiological Pattern in an Epidemic of Acute Febrile Illness during Monsoon in a Tertiary Health Care Institute of Uttarakhand,India[J]. J Clin Diagn Res,2014,8(6):1-3., http://www.100md.com(蒋连保 廖运学 黄小都 谢峰云 李立军 龙新山)
参考文献
[1] Kar A,Dhanaraj M,Dedeepiya D,et al. Acute encephalitis syndrome following scrub typhus infection [J].Indian J Crit Care Med,2014,18(7):453-455.
[2] 陈灏珠,钟南山,陆再英,等.内科学[M].第8版.北京:人民卫生出版社,2013:282-284.
[3] Griffith M,Peter JV,Karthik G,et al.Profile of organ dysfunction and predictors of mortality in severe scrub typhus infection requiring intensive care admission.[J].Indian J Crit Care Med,2014,18(8):497-502.
[4] Keller CA,Hauptmann M,Kolbaum J,et al.Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus.[J].PLoS Negl Trop Dis,2014,8(8):30-64.
[5] Singh R,Singh SP,Ahmad N.et al.A Study of Etiological Pattern in an Epidemic of Acute Febrile Illness during Monsoon in a Tertiary Health Care Institute of Uttarakhand,India[J]. J Clin Diagn Res,2014,8(6):1-3., http://www.100md.com(蒋连保 廖运学 黄小都 谢峰云 李立军 龙新山)