Th17与类风湿关节炎研究进展(3)
[4]Bettelli E，Carrier Y，Gao W，et al. Rcciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].Nature，2006,441:235-238.
[5]Gorelik L,Flaveil R A.Abrogation of TGF-βsignaling in T cells leads to spontaneous T cell differentiation and autoimmune disease[J]. Immunity，2000,12:171-181.
[6]Langrisiicl，Chen Y,Biumenschein WM，et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].Exp Med，2005，201:233-240.
, 百拇医药
[7]Chen Z，Laurence A，Kanno Y，et al. Selective regulatory function of Socs3 in the formation of lL-17-secretingT cells[J].PNAS，2006，103:8137-8142.
[8]Wahl SM，Wen J，Moutsopoulos N.TGF-beta : a mobile purveyor of immune privilege[J].Immunol Rev,2006,213:213-217.
[9]Harrington L E，Hatton R D，Mangan P R，et al.Interleukinl7-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J].Nat lmmunol，2005，6(11):1123-1132.
, 百拇医药
[10]Sujata Sarkar, Laura A,Tesmer, et al.Interleukin-17 as a Molecular Target in Immune-Mediated Arthritis. ARTHRITIS & RHEUMATISM, 2007, 56: 89-100.
[11]Xuexian O，Yang, Bhanu P，Pappu J,et al.T Helper17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors ROR(and RORγ[J].immuni，2007,11:29-39.
[12]Reinhardtrl，Kangs J，Lianghe，et al. T helper cell effector fates—who，how and where[J].Curr opin Immunol，2006,15:271-277.
, 百拇医药
[13]Bush KA，Walker JS，Lee CS，et a1.Cytokine expression and synovia pathology in the initiation and spontaneous resolution phases of adja- van arthritis：interleukin-17 expression is upregulated in early disease[J].Clin Exp lmmunol，2001,123:487-495.
[14]Bush KA, Farmer KM,Walker JS, et al. Reduction of joint inflammation and boneerosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1Fc fusion protein[J].Arthritis Rheum, 2002,46:802-805.
, http://www.100md.com
[15]Dudler J，Renggli Zulliger N，Busso N，et a1.Effect of interleukin 17 on proteoglycan degradation in murine knee joints[J].Ann Rheum- Dis，2000,597:529-532.
[16]Lubberts E，Joosten LA，Van deloo FA，et a1.Reduction of interleukin-17-induced inhibition of chonodrocyte proteoglycan synthesis in intact murine articular cartilage by intefleukin-4 [J].Arthritis Rheum，2000,43:1300-l306.
[17]Numasaki M，Fukushi J，Ono M，et a1.Interleukin-17 promotes angiogenesis and tumor growth[J].Blood，2003,101:735-738.
, 百拇医药
[18]Koenders MI, Lubberts E, OppersWalgreen B, et al. Am J Pathol, 2005,167:141-149.
[19]Lubberts E，van den Bersselaar L,Oppers-Walgreen B,et a1.J Immuno1,2003,170:2655-2662.
[20]秦霞，刘钟滨.白细胞介素17家族[J].同济大学学报医学版，2003,24:519-522.
[21]J Biol Chem. Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells.The Journal of Immunology,2008,181:2799-2805.
, 百拇医药
[22]Wong PK，Campbell IK，Egan PJ，et a1.The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turn.Over [J].Arthritis Rheum，2003,48:ll77-ll89.
[23]孙晓云.甲氨蝶呤对类风湿关节炎患者的治疗作用及对相关细胞因子的影响[J].北京大学学报医学版，2006,38:356-359.
[24]王志坚 万军梅.甲喋呤对类风湿性关节炎患者外周血单个核细胞产生细胞因子的影响[J].中国药理学通报,1998,14:367-369., 百拇医药(丁 琴 何东仪)
[5]Gorelik L,Flaveil R A.Abrogation of TGF-βsignaling in T cells leads to spontaneous T cell differentiation and autoimmune disease[J]. Immunity，2000,12:171-181.
[6]Langrisiicl，Chen Y,Biumenschein WM，et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].Exp Med，2005，201:233-240.
, 百拇医药
[7]Chen Z，Laurence A，Kanno Y，et al. Selective regulatory function of Socs3 in the formation of lL-17-secretingT cells[J].PNAS，2006，103:8137-8142.
[8]Wahl SM，Wen J，Moutsopoulos N.TGF-beta : a mobile purveyor of immune privilege[J].Immunol Rev,2006,213:213-217.
[9]Harrington L E，Hatton R D，Mangan P R，et al.Interleukinl7-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J].Nat lmmunol，2005，6(11):1123-1132.
, 百拇医药
[10]Sujata Sarkar, Laura A,Tesmer, et al.Interleukin-17 as a Molecular Target in Immune-Mediated Arthritis. ARTHRITIS & RHEUMATISM, 2007, 56: 89-100.
[11]Xuexian O，Yang, Bhanu P，Pappu J,et al.T Helper17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors ROR(and RORγ[J].immuni，2007,11:29-39.
[12]Reinhardtrl，Kangs J，Lianghe，et al. T helper cell effector fates—who，how and where[J].Curr opin Immunol，2006,15:271-277.
, 百拇医药
[13]Bush KA，Walker JS，Lee CS，et a1.Cytokine expression and synovia pathology in the initiation and spontaneous resolution phases of adja- van arthritis：interleukin-17 expression is upregulated in early disease[J].Clin Exp lmmunol，2001,123:487-495.
[14]Bush KA, Farmer KM,Walker JS, et al. Reduction of joint inflammation and boneerosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1Fc fusion protein[J].Arthritis Rheum, 2002,46:802-805.
, http://www.100md.com
[15]Dudler J，Renggli Zulliger N，Busso N，et a1.Effect of interleukin 17 on proteoglycan degradation in murine knee joints[J].Ann Rheum- Dis，2000,597:529-532.
[16]Lubberts E，Joosten LA，Van deloo FA，et a1.Reduction of interleukin-17-induced inhibition of chonodrocyte proteoglycan synthesis in intact murine articular cartilage by intefleukin-4 [J].Arthritis Rheum，2000,43:1300-l306.
[17]Numasaki M，Fukushi J，Ono M，et a1.Interleukin-17 promotes angiogenesis and tumor growth[J].Blood，2003,101:735-738.
, 百拇医药
[18]Koenders MI, Lubberts E, OppersWalgreen B, et al. Am J Pathol, 2005,167:141-149.
[19]Lubberts E，van den Bersselaar L,Oppers-Walgreen B,et a1.J Immuno1,2003,170:2655-2662.
[20]秦霞，刘钟滨.白细胞介素17家族[J].同济大学学报医学版，2003,24:519-522.
[21]J Biol Chem. Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells.The Journal of Immunology,2008,181:2799-2805.
, 百拇医药
[22]Wong PK，Campbell IK，Egan PJ，et a1.The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turn.Over [J].Arthritis Rheum，2003,48:ll77-ll89.
[23]孙晓云.甲氨蝶呤对类风湿关节炎患者的治疗作用及对相关细胞因子的影响[J].北京大学学报医学版，2006,38:356-359.
[24]王志坚 万军梅.甲喋呤对类风湿性关节炎患者外周血单个核细胞产生细胞因子的影响[J].中国药理学通报,1998,14:367-369., 百拇医药(丁 琴 何东仪)