艾司奥美拉唑钠针剂与兰索拉唑针剂治疗消化道溃疡所致急性上消化道出血的疗效差异研究(1)
【摘 要】目的：研究艾司奥美拉唑钠针剂与兰索拉唑针剂治疗消化道溃疡所致急性上消化道出血的疗效差异。方法：选取2015年10月～2017年10月我院收治的消化道溃疡致急性上消化道出血患者102例，按照随机分配原则分为对照组和观察组，各51例。对照组给予兰索拉唑针剂治疗，观察组艾司奥美拉唑钠针剂给予治疗，对比两组临床疗效、止血时间、腹痛缓解时间、血压稳定时间、pH值改善情况以及不良反应发生情况。结果：观察组治疗总有效率、止血时间、血压稳定时间、腹痛缓解时间以及平pH值改善程度均显著有对照组(P<0.05)，差异有统计学意义；观察组不良反应发生率与对照组并无明显差异(P>0.05)。结论：采用艾司奥美拉唑钠针剂治疗消化道溃疡所致的急性上消化道出血疗效相比兰索拉唑针剂更为显著，可改善胃液pH值并快速稳定血压，用药安全性高，值得推广。
【关键词】消化道溃疡；急性上消化道出血；艾司奥美拉唑钠；兰索拉唑；臨床疗效
【中图分类号】R47
, 百拇医药
【文献标志码】B
【文章编号】1005-0019(2018)05-008-01
Abstract Objective：To study the difference between esomeprazole sodium injection and lansoprazole injection in the treatment of acute upper gastrointestinal bleeding caused by peptic ulcer.Methods： 102 cases of acute upper gastrointestinal bleeding caused by peptic ulcers in our hospital in October ～2017 in October 2015 were selected and divided into control grouPand observation grouPaccording to the principle of random distribution，51 cases in each group.The control grouPwas treated with lansoprazole injection，and the observation grouPwas treated with omeprazole sodium injection.The clinical effect，the time of hemostasis，the relieving time of abdominal pain，the time of the stability of blood pressure，the improvement of pH value and the occurrence of adverse reaction were compared between the two groups.Results： the total effective rate，hemostasis time，blood pressure stability time，abdominal pain relief time and the improvement of pH value were all significantly in the control grouP(P< 0.05)，the difference was statistically significant，and there was no significant difference in the incidence of adverse reactions between the observation grouPand the control grouP(P> 0.05). Conclusion： the effect of the injection of esomeprazole sodium in the treatment of acute upper gastrointestinal bleeding caused by peptic ulcer is more significant than that of lansoprazole.It can improve the pH value of gastric juice and quickly stabilize the blood pressure.It is highly safe and worthy of promotion.
, 百拇医药
Key words： peptic ulcer；acute upper gastrointestinal hemorrhage；esomeprazole sodium；lansoprazole；clinical curative effect
急性上消化道出血是一种临床少较为常见的消化系统疾病，属于消化道溃疡常见的并发症之一，其具有病情危急的特点，若是不及时进行治疗有可能危及患者生命安全[1]。艾司奥美拉唑钠和兰索拉唑是临床上治疗急性上消化道出血常用的两种质子泵抑制剂，均具有较为显著逇抑酸效果，可有效缓解病人症状[2]。本文旨在兰索拉唑与艾司奥美拉唑钠治疗消化道溃疡导致的急性上消化道出血的临床疗效进行对比分析，具体报道如下。
1 资料与方法
1.1 一般资料 选取我院2015年10月～2017年10月收治的102例上消化道溃疡引起的急性上消化道出血患者，按照疗法不同分为对照组、观察组。对照组51例，男26例，女25例，年龄32～65岁，平均年龄(42.29±3.62)岁，出血时间1～3d，平均出血时间(2.05±0.76)d，其中胃溃疡出血36例，十二指肠溃疡出血8例，复合型溃疡出血7例；观察组51例，男28例，女23例，年龄31～67岁，平均年龄(43.29±3.81)岁，出血时间1～4d，平均出血时间(2.15±0.84)d，其中胃溃疡出血34例，十二指肠溃疡出血9例，复合型溃疡出血8例。将两组患者性别、年龄、出血时间等一般资料进行对比，P>0.05，有可比性。, 百拇医药(赵翠萍)
【关键词】消化道溃疡；急性上消化道出血；艾司奥美拉唑钠；兰索拉唑；臨床疗效
【中图分类号】R47
, 百拇医药
【文献标志码】B
【文章编号】1005-0019(2018)05-008-01
Abstract Objective：To study the difference between esomeprazole sodium injection and lansoprazole injection in the treatment of acute upper gastrointestinal bleeding caused by peptic ulcer.Methods： 102 cases of acute upper gastrointestinal bleeding caused by peptic ulcers in our hospital in October ～2017 in October 2015 were selected and divided into control grouPand observation grouPaccording to the principle of random distribution，51 cases in each group.The control grouPwas treated with lansoprazole injection，and the observation grouPwas treated with omeprazole sodium injection.The clinical effect，the time of hemostasis，the relieving time of abdominal pain，the time of the stability of blood pressure，the improvement of pH value and the occurrence of adverse reaction were compared between the two groups.Results： the total effective rate，hemostasis time，blood pressure stability time，abdominal pain relief time and the improvement of pH value were all significantly in the control grouP(P< 0.05)，the difference was statistically significant，and there was no significant difference in the incidence of adverse reactions between the observation grouPand the control grouP(P> 0.05). Conclusion： the effect of the injection of esomeprazole sodium in the treatment of acute upper gastrointestinal bleeding caused by peptic ulcer is more significant than that of lansoprazole.It can improve the pH value of gastric juice and quickly stabilize the blood pressure.It is highly safe and worthy of promotion.
, 百拇医药
Key words： peptic ulcer；acute upper gastrointestinal hemorrhage；esomeprazole sodium；lansoprazole；clinical curative effect
急性上消化道出血是一种临床少较为常见的消化系统疾病，属于消化道溃疡常见的并发症之一，其具有病情危急的特点，若是不及时进行治疗有可能危及患者生命安全[1]。艾司奥美拉唑钠和兰索拉唑是临床上治疗急性上消化道出血常用的两种质子泵抑制剂，均具有较为显著逇抑酸效果，可有效缓解病人症状[2]。本文旨在兰索拉唑与艾司奥美拉唑钠治疗消化道溃疡导致的急性上消化道出血的临床疗效进行对比分析，具体报道如下。
1 资料与方法
1.1 一般资料 选取我院2015年10月～2017年10月收治的102例上消化道溃疡引起的急性上消化道出血患者，按照疗法不同分为对照组、观察组。对照组51例，男26例，女25例，年龄32～65岁，平均年龄(42.29±3.62)岁，出血时间1～3d，平均出血时间(2.05±0.76)d，其中胃溃疡出血36例，十二指肠溃疡出血8例，复合型溃疡出血7例；观察组51例，男28例，女23例，年龄31～67岁，平均年龄(43.29±3.81)岁，出血时间1～4d，平均出血时间(2.15±0.84)d，其中胃溃疡出血34例，十二指肠溃疡出血9例，复合型溃疡出血8例。将两组患者性别、年龄、出血时间等一般资料进行对比，P>0.05，有可比性。, 百拇医药(赵翠萍)
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