重组人脑利钠肽辅助介入术对急性心肌梗死合并心源性休克患者炎症因子的影响(1)
【摘要】目的：探讨急性心肌梗死合并心源性休克患者采用重组人脑利钠肽辅助介入治疗的临床效果。方法：选择2016年10月-2018年5月商丘市第一人民医院急诊心内科收治的急性心肌梗死合并心源性休克患者60例，使用随机数表法将所有患者分为2组，各30例。对照组予以予以常规介入治疗，观察组在术前予以重组人脑利钠肽辅助治疗，比较两组患者炎症因子水平及心肌酶谱指标变化情况。结果：与对照组相比，治疗后观察组患者各炎症因子水平及心肌酶谱指标水平均较低，差异有统计学意义(P<005)。结论：重组人脑利钠肽辅助介入治疗可对急性心肌梗死合并心源性休克患者正常心肌功能形成良好的保护作用，同时可降低机体炎症反应，有利于改善患者预后。
【关键词】急性心肌梗死；心源性休克；重组人脑利钠肽；炎症因子
【中图分类号】R54222
【文献标志码】B
【文章编号】1005-0019(2018)07-017-01
, http://www.100md.com
Effect of recombinant human brain natriuretic peptide Assisted Intervention on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock
Su Jiankang (Department of Cardiology， Department of Cardiology， Shangqiu First People's Hospital， Henan， Shangqiu， 476100)， CCU
Abstract Objective：To investigate the clinical effect of recombinant human brain natriuretic peptide (BNP) in patients with acute myocardial infarction complicated with cardiogenic shock. Methods： 60 patients with acute myocardial infarction combined with cardiogenic shock treated in the emergency department of Cardiology， Shangqiu First People's Hospital， October 2016 -2018， were divided into 2 groups， 30 cases each with random digital meter. The control group was given routine interventional therapy， and the observation group was treated with recombinant human brain natriuretic peptide before operation， and the level of inflammatory factors and the changes of myocardial enzyme spectrum index were compared between the two groups.Results： compared with the control group， the levels of inflammatory factors and myocardial enzyme spectrum index of the patients in the observation group were lower than those in the control group， and the difference was statistically significant (P<005). Conclusion： recombinant human brain natriuretic peptide assisted interventional therapy can protect the normal myocardial function of patients with acute myocardial infarction combined with cardiogenic shock， and can reduce the inflammatory response and improve the prognosis of the patients.
, 百拇医药
Key words： acute myocardial infarction； cardiogenic shock； recombinant human brain natriuretic peptide； inflammatory factor
心源性休克為急性心肌梗死后常出现症状，对于发病12h内患者可接受经皮冠状动脉介入治疗(PCI)，但术后远端血管易发生重复梗死进而引发受损心肌持续性灌流中断，导致心功能进一步受损等[1]。脑钠肽为生物活性多钠，具有利尿利钠作用，且可维持水电解质平衡；重组人脑利钠肽是利用重组DNA技术而产生的无菌冻干制剂，与脑钠肽具有相同的生物活性与氨基酸序列，可发挥降低心脏前后负荷等作用[2]。鉴于此，本研究将重组人脑利钠肽加入PCI介入治疗方案中，以探讨其对患者炎症因子水平的影响。具体信息如下。
1资料与方法
11一般资料选择2016年10月-2018年5月商丘市第一人民医院急诊心内科收治的急性心肌梗死合并心源性休克患者60例，使用随机数表法将所有患者分为2组，各30例。观察组男17例，女13例；年龄51-76岁，平均(6419±328)岁。对照组男16例，女14例；年龄52-76岁，平均(6421±325)岁。本研究经我院伦理委员会批准，且所有患者均自愿参与并签署知情同意书。两组患者一般资料相比，差异无统计学意义(P>005)，具有可对比性。, 百拇医药(苏健康)
【关键词】急性心肌梗死；心源性休克；重组人脑利钠肽；炎症因子
【中图分类号】R54222
【文献标志码】B
【文章编号】1005-0019(2018)07-017-01
, http://www.100md.com
Effect of recombinant human brain natriuretic peptide Assisted Intervention on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock
Su Jiankang (Department of Cardiology， Department of Cardiology， Shangqiu First People's Hospital， Henan， Shangqiu， 476100)， CCU
Abstract Objective：To investigate the clinical effect of recombinant human brain natriuretic peptide (BNP) in patients with acute myocardial infarction complicated with cardiogenic shock. Methods： 60 patients with acute myocardial infarction combined with cardiogenic shock treated in the emergency department of Cardiology， Shangqiu First People's Hospital， October 2016 -2018， were divided into 2 groups， 30 cases each with random digital meter. The control group was given routine interventional therapy， and the observation group was treated with recombinant human brain natriuretic peptide before operation， and the level of inflammatory factors and the changes of myocardial enzyme spectrum index were compared between the two groups.Results： compared with the control group， the levels of inflammatory factors and myocardial enzyme spectrum index of the patients in the observation group were lower than those in the control group， and the difference was statistically significant (P<005). Conclusion： recombinant human brain natriuretic peptide assisted interventional therapy can protect the normal myocardial function of patients with acute myocardial infarction combined with cardiogenic shock， and can reduce the inflammatory response and improve the prognosis of the patients.
, 百拇医药
Key words： acute myocardial infarction； cardiogenic shock； recombinant human brain natriuretic peptide； inflammatory factor
心源性休克為急性心肌梗死后常出现症状，对于发病12h内患者可接受经皮冠状动脉介入治疗(PCI)，但术后远端血管易发生重复梗死进而引发受损心肌持续性灌流中断，导致心功能进一步受损等[1]。脑钠肽为生物活性多钠，具有利尿利钠作用，且可维持水电解质平衡；重组人脑利钠肽是利用重组DNA技术而产生的无菌冻干制剂，与脑钠肽具有相同的生物活性与氨基酸序列，可发挥降低心脏前后负荷等作用[2]。鉴于此，本研究将重组人脑利钠肽加入PCI介入治疗方案中，以探讨其对患者炎症因子水平的影响。具体信息如下。
1资料与方法
11一般资料选择2016年10月-2018年5月商丘市第一人民医院急诊心内科收治的急性心肌梗死合并心源性休克患者60例，使用随机数表法将所有患者分为2组，各30例。观察组男17例，女13例；年龄51-76岁，平均(6419±328)岁。对照组男16例，女14例；年龄52-76岁，平均(6421±325)岁。本研究经我院伦理委员会批准，且所有患者均自愿参与并签署知情同意书。两组患者一般资料相比，差异无统计学意义(P>005)，具有可对比性。, 百拇医药(苏健康)
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