对抑郁症患者给予草酸艾司西酞普兰与盐酸帕罗西汀联合治疗的效果观察(1)
【摘 要】目的:探索草酸艾司酞普兰与盐酸帕罗西汀联合治疗抑郁症的效果。方法:选择抑郁症100例,选择时间:2017年3月21日-2018年4月30日,分别行不同的治疗模式:盐酸帕罗西汀治疗、草酸艾司西酞普兰联合盐酸帕罗西汀治疗,对应组别:对照组、观察组。比较2组汉密尔顿抑郁量表评分(HAMD)、临床疗效、不良反应发生情况。结果:观察组治疗第2周、第4周、第8周汉密尔顿抑郁量表评分优于对照组,临床疗效高于对照组,不良反应发生情况低于对照组,P<0.05。结论:草酸艾司西酞普兰与盐酸帕罗西汀联合治疗抑郁症效果较佳,可推广。
【关键词】抑郁症;草酸艾司西酞普兰;盐酸帕罗西汀;效果观察
Effect of Combined Treatment with Escitalopram Oxalate and Paroxetine Hydrochloride in Patients with Depression
, 百拇医药
LIJi[Longchang Psychiatric Hospital of Sichuan(The Second people's Hospital of Longchang City Sichuan Province ),Longchang,Sichuan]
Abstract:Objective To explore the effect of escitalopram oxalate combined with paroxetine hydrochloride in the treatment of depression. Methods: 100 cases of depression were selected. The choice time was from March 21st, 2017 to April 30th, 2017. Different treatment modes were treated: paroxetine hydrochloride, escitalopram oxalate combined with paroxetine hydrochloride, corresponding group Do not: control group, observation group. The two groups of Hamilton Depression Rating Scale (HAMD), clinical efficacy, and adverse reactions were compared. Results: In the observation group, the Hamilton Depression Scale score was better than that of the control group at the 2nd, 4th, and 8th week. The clinical effect was higher than that of the control group, and the adverse reaction was lower than the control group, P<0.05. Conclusion: The combination of escitalopram oxalate and paroxetine hydrochloride is effective in the treatment of depression and can be promoted.
, 百拇医药
Key words: depression; escitalopram oxalate; paroxetine hydrochloride; effect observation
【中图分类号】R749. 7 【文献标识码】A 【文章编号】1005-0019(2018)15-0-01
抑郁症是一种较为常见的心理障碍类型疾病,其病因较多,一般以情绪低落、复发率、发病率较高为主要临床表现[1],臨床针对此类疾病一般选择药物治疗,缓解患者抑郁状况,从而提升患者生活质量。本文就100例抑郁症患者分别给予不同手段进行治疗,对比差异性,具体情况如下文所示:
1 资料和方法
1.1 资料 选择抑郁症100例,选择时间:2017年3月21日-2018年4月30日,随机分2组。本研究符合医学实验伦理学原则,经医院伦理学委员会批准,且2组均符合纳入及排除标准,纳入标准:(1)经临床综合检查,证实为抑郁症;(2)汉密尔顿抑郁量表总分分值大于18分[2];(3)入组前并未选择其他药物治疗;(4)对研究知情同意。排除标准:(1)不配合研究者;(2)对此次研究药物存在过敏史;(3)临床资料不全;(4)合并其它全身性疾病者。对照组—31例男性,19例女性,平均年龄为(40.23±3.33)岁,平均病程为(3.23±0.54)年;观察组—32例男性,18例女性,平均年龄为(41.57±3.54)岁,平均病程为(3.32±0.55)年;经SPSS21.0系统分析组间的基线资料数据指标差异,无差异性,P>0.05。
1.2 方法 对照组—盐酸帕罗西汀治疗:口服盐酸帕罗西汀(国药准字H20040533;浙江尖峰药业有限公司;20mg),初始剂量为10mg,之后根据患者病情逐渐增加至每天60mg;观察组:草酸艾司西酞普兰联合盐酸帕罗西汀治疗:口服草酸艾司西酞普兰(国药准字H20103548;山东京卫制药有限公司;20mg),初始剂量为10mg,之后根据患者病情逐渐增加至20mg,同时口服盐酸帕罗西汀(国药准字H20040533;浙江尖峰药业有限公司;20mg),初始剂量为10mg,之后增加至60mg;2组均治疗8周。, http://www.100md.com(李姬)
【关键词】抑郁症;草酸艾司西酞普兰;盐酸帕罗西汀;效果观察
Effect of Combined Treatment with Escitalopram Oxalate and Paroxetine Hydrochloride in Patients with Depression
, 百拇医药
LIJi[Longchang Psychiatric Hospital of Sichuan(The Second people's Hospital of Longchang City Sichuan Province ),Longchang,Sichuan]
Abstract:Objective To explore the effect of escitalopram oxalate combined with paroxetine hydrochloride in the treatment of depression. Methods: 100 cases of depression were selected. The choice time was from March 21st, 2017 to April 30th, 2017. Different treatment modes were treated: paroxetine hydrochloride, escitalopram oxalate combined with paroxetine hydrochloride, corresponding group Do not: control group, observation group. The two groups of Hamilton Depression Rating Scale (HAMD), clinical efficacy, and adverse reactions were compared. Results: In the observation group, the Hamilton Depression Scale score was better than that of the control group at the 2nd, 4th, and 8th week. The clinical effect was higher than that of the control group, and the adverse reaction was lower than the control group, P<0.05. Conclusion: The combination of escitalopram oxalate and paroxetine hydrochloride is effective in the treatment of depression and can be promoted.
, 百拇医药
Key words: depression; escitalopram oxalate; paroxetine hydrochloride; effect observation
【中图分类号】R749. 7 【文献标识码】A 【文章编号】1005-0019(2018)15-0-01
抑郁症是一种较为常见的心理障碍类型疾病,其病因较多,一般以情绪低落、复发率、发病率较高为主要临床表现[1],臨床针对此类疾病一般选择药物治疗,缓解患者抑郁状况,从而提升患者生活质量。本文就100例抑郁症患者分别给予不同手段进行治疗,对比差异性,具体情况如下文所示:
1 资料和方法
1.1 资料 选择抑郁症100例,选择时间:2017年3月21日-2018年4月30日,随机分2组。本研究符合医学实验伦理学原则,经医院伦理学委员会批准,且2组均符合纳入及排除标准,纳入标准:(1)经临床综合检查,证实为抑郁症;(2)汉密尔顿抑郁量表总分分值大于18分[2];(3)入组前并未选择其他药物治疗;(4)对研究知情同意。排除标准:(1)不配合研究者;(2)对此次研究药物存在过敏史;(3)临床资料不全;(4)合并其它全身性疾病者。对照组—31例男性,19例女性,平均年龄为(40.23±3.33)岁,平均病程为(3.23±0.54)年;观察组—32例男性,18例女性,平均年龄为(41.57±3.54)岁,平均病程为(3.32±0.55)年;经SPSS21.0系统分析组间的基线资料数据指标差异,无差异性,P>0.05。
1.2 方法 对照组—盐酸帕罗西汀治疗:口服盐酸帕罗西汀(国药准字H20040533;浙江尖峰药业有限公司;20mg),初始剂量为10mg,之后根据患者病情逐渐增加至每天60mg;观察组:草酸艾司西酞普兰联合盐酸帕罗西汀治疗:口服草酸艾司西酞普兰(国药准字H20103548;山东京卫制药有限公司;20mg),初始剂量为10mg,之后根据患者病情逐渐增加至20mg,同时口服盐酸帕罗西汀(国药准字H20040533;浙江尖峰药业有限公司;20mg),初始剂量为10mg,之后增加至60mg;2组均治疗8周。, http://www.100md.com(李姬)
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