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Biology of Cancer Cell: Understanding the transport defect that influe(2)
http://www.100md.com 2019年3月1日 《健康大视野》 2019年第5期
     Transport Defect to Cancer Cell

    According to current evidence on cancer cells development, it is clear that mitochondria is the main role player. Since mitochondria is the subordinate component of the cell, it is responsible for most of the functions that take place in the cell nuclear. In this case, if a mitochondria dysfunctions, it leads to a high level of pathological conditions such as cardiovascular conditions and cancer. This is based on the cell homeostasis which is more complex than metabolism. . the ability that mitochondria has in controlling function makes the situation complex if it is dysfunction since it guards or rather regulate the death of programmed cells in organisms. In this case, normal cells grow and divide in accordance with the cell cycle.
, 百拇医药
    However, this normal cell division is normally altered by mutation leading to an abnormal cell division. Cancer is a condition where body cells divide abnormally leading to growth of body tumors. Never the less not all genes in the body are associated with cancer. The three categories of genes associated with cancer are; proto-oncogenes, tumor suppressors, and the third group contain the DNA repair genes, (Brody, 2014).

    Glycolysis has been considered the most important metabolic process in the cells especially in the growth of cancer cells. Though, the process has effectively been used in clinics for imaging, mitochondria have now been determined as the main role players in oncogenesis. Mitochondria are the building blocks for tumor anabolicis in the cells and calcium homeostasis, (Hung et al, 2015). As much it governs cell death, it also responsible in producing energy used by the cell to function. In the basis of transportation defect, mitochondria are the main elements that always come into action causing cell dysfunction, since they have been attacked by external or even internal factors that alters cell functioning. Moreover, cancer is caused by mutations within the tumor suppressor genes and oncogenes. The cells that cause cancer operate independently as they divide uncontrollably to form tumors.
, 百拇医药
    There are different types of cancer depending on the type of cell altered namely; Carcinomas, Sarcomas, Leukemia, Lymphoma, and Myelomas. In addition, cancer has proved hard to contain, however it can be detected through emerging technologies like MRI, X-rays, and ultrasound. In this case, focus will be directed to the intrinsic and extrinsic mechanism that mitochondria can be involved in that highly influence the processes of oncogenesis, (Jian et al, 2015)., 百拇医药(Yujia Ji)
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