帕罗西汀联合心理干预对伴发抑郁症的功能性消化不良患者的效果(1)
【摘 要】 目的：探究功能性消化不良伴发抑郁症患者采取帕罗西汀联合心理干预的临床疗效。方法：入选病例选取我院2016年10月-2018年10月期间收治的66例功能性消化不良伴发抑郁症患者，按随机数表法分成对照组(33例)与观察组(33例)，对照组给予常规抑酸、促胃动力治疗，观察组在对照组基础上使用帕罗西汀联合心理干预，比较两组治疗前后抑郁程度、胃肠道排空率及安全性。结果：两组治疗后抑郁程度均较治疗前减轻，且观察组抑郁程度低于对照组，差异有统计学意义(P<0.05);治疗后，观察组餐后5h、3d胃肠排空率均高于对照组，差异有统计学意义(P<0.05);两组不良反应发生率相比，差异无统计学意义(P>0.05)。结论：伴发抑郁症的功能消化不良患者采取帕罗西汀治疗联合心理干预，可改善患者抑郁心理，提高胃肠排空率，且不良反应较少，具有较高的安全性。
【關键词】 功能性消化不良;帕罗西汀;心理干预;抑郁症
【中图分类号】 R248 【文献标志码】B 【文章编号】1005-0019(2019)19-008-01
Abstract：objective to explore the clinical efficacy of paroxetine combined with psychological intervention in patients with functional dyspepsia associated with depression.Method： selected cases selected from October 2016 to October 2018 admitted during the period of 66 patients with functional dyspepsia patients with comorbid depression， according to the stochastic indicator method is divided into the control group (33 cases) and observation group (33 cases)， control group given conventional acid suppression， promote gastric dynamic treatment， observation group in the control group using paroxetine combined psychological intervention， on the basis of comparing the two groups before and after treatment the degree of depression， gastrointestinal emptying rate and safety. Results： the depression degree of the two groups after treatment was lower than that before treatment， and the depression degree of the observation group was lower than that of the control group， the difference was statistically significant (P < 0.05). After treatment， the gastrointestinal emptying rate in the observation group was higher than that in the control group at 5h and 3d after meal， and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion： the combination of paroxetine therapy and psychological intervention in patients with functional dyspepsia associated with depression can improve the patients' depressive psychology， improve the rate of gastrointestinal emptying， and have fewer adverse reactions， so it has higher safety.
Key words：functional dyspepsia; Paxil; Psychological intervention; depression
功能性消化不良为消化科常见的一种非器质性病变，发病率约占全部消化系统疾病的30-50%，严重影响生活与工作，目前，其发病原因尚不明确，通常认为与胃酸分泌异常、胃动力障碍、精神因素、环境因素具有密切联系，既往临床主要针对疾病生理病理进行治疗，往往忽略精神、心理层面的重视，导致临床疗效欠佳[1]。部分功能性消化不良患者伴发抑郁症，应重视精神类药物的应用，控制患者焦虑、抑郁状态[2]。本研究旨在探讨功能性消化不良伴发抑郁症患者采取帕罗西汀联合心理干预对患者抑郁情绪的改善效果及对胃肠排空率的影响。现报道如下。, http://www.100md.com(杜志国)
【關键词】 功能性消化不良;帕罗西汀;心理干预;抑郁症
【中图分类号】 R248 【文献标志码】B 【文章编号】1005-0019(2019)19-008-01
Abstract：objective to explore the clinical efficacy of paroxetine combined with psychological intervention in patients with functional dyspepsia associated with depression.Method： selected cases selected from October 2016 to October 2018 admitted during the period of 66 patients with functional dyspepsia patients with comorbid depression， according to the stochastic indicator method is divided into the control group (33 cases) and observation group (33 cases)， control group given conventional acid suppression， promote gastric dynamic treatment， observation group in the control group using paroxetine combined psychological intervention， on the basis of comparing the two groups before and after treatment the degree of depression， gastrointestinal emptying rate and safety. Results： the depression degree of the two groups after treatment was lower than that before treatment， and the depression degree of the observation group was lower than that of the control group， the difference was statistically significant (P < 0.05). After treatment， the gastrointestinal emptying rate in the observation group was higher than that in the control group at 5h and 3d after meal， and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion： the combination of paroxetine therapy and psychological intervention in patients with functional dyspepsia associated with depression can improve the patients' depressive psychology， improve the rate of gastrointestinal emptying， and have fewer adverse reactions， so it has higher safety.
Key words：functional dyspepsia; Paxil; Psychological intervention; depression
功能性消化不良为消化科常见的一种非器质性病变，发病率约占全部消化系统疾病的30-50%，严重影响生活与工作，目前，其发病原因尚不明确，通常认为与胃酸分泌异常、胃动力障碍、精神因素、环境因素具有密切联系，既往临床主要针对疾病生理病理进行治疗，往往忽略精神、心理层面的重视，导致临床疗效欠佳[1]。部分功能性消化不良患者伴发抑郁症，应重视精神类药物的应用，控制患者焦虑、抑郁状态[2]。本研究旨在探讨功能性消化不良伴发抑郁症患者采取帕罗西汀联合心理干预对患者抑郁情绪的改善效果及对胃肠排空率的影响。现报道如下。, http://www.100md.com(杜志国)
参见：首页 > 医疗版 > 疾病专题 > 小儿科 > 消化系统和营养障碍性疾病 > 消化不良