【摘 要】目的：分析枸地氯雷他定+非索非那定治疗难治性荨麻疹的疗效。方法：在我院收治的难治性荨麻疹患者中选取58例，起止时间是2017年3月～2019年6月。分为2个小组：对照组29例，单独使用枸地氯雷他定;试验组29例，联合应用非索非那定。评定临床疗效。结果：试验组总有效28例(96.6%)，高于对照组的22例(75.9%);治疗后，试验组CD3+、CD4+、CD4+/CD8+指标更高(P<0.05)。结论：枸地氯雷他定+非索非那定治疗难治性荨麻疹疗效确切，有利于提高患者的免疫能力，值得推广。

    【关键词】难治性荨麻疹;枸地氯雷他定;非索非那定;免疫指标

    Abstract：Objective To analyze the efficacy of loratadine citrate plus fexofenadine in the treatment of refractory urticaria. Methods： 58 patients with refractory urticaria were selected from March 2017 to June 2019. They were divided into two groups： the control group (29 cases) treated with loratadine citrate alone and the experimental group (29 cases) treated with fexofenadine in combination. To evaluate the clinical efficacy. Results： 28 cases (96.6%) were effective in the experimental group ......